Anti-CD130 (gp130)抗体[B-R3] (ab47217)

概述

  • 产品名称Anti-CD130 (gp130)抗体[B-R3]
    参阅全部 CD130 (gp130) 一抗
  • 描述
    小鼠单克隆抗体[B-R3] to CD130 (gp130)
  • 经测试应用适用于: Flow Cyt, Inhibition Assaymore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Natural soluble human CD130 (gp130).

  • 常规说明


    This antibody recognizes the soluble antigen of CD130 (gp130).

性能

应用

Our Abpromise guarantee covers the use of ab47217 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use at an assay dependent concentration.

Use 0.5µg/test.





ab170191-Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
Inhibition Assay Use at an assay dependent concentration.

Use 1/10 dilution from 50µg/ml to 10-1 µg/ml. Inhibits IL6, IL11, CNTF, LIF and OSM activities as well as OSM and CNTF binding to gp130.

靶标

  • 功能Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events.
  • 组织特异性Found in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells.
  • 序列相似性Belongs to the type I cytokine receptor family. Type 2 subfamily.
    Contains 5 fibronectin type-III domains.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • 结构域The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.
  • 翻译后修饰Phosphorylation of Ser-782 down-regulates cell surface expression.
    Heavily N-glycosylated.
  • 细胞定位Secreted and Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CD130 antibody
    • CD130 antigen antibody
    • CDw130 antibody
    • gp130 antibody
    • GP130 RAPS antibody
    • IL 6R beta antibody
    • IL-6 receptor subunit beta antibody
    • IL-6R subunit beta antibody
    • IL-6R-beta antibody
    • IL-6RB antibody
    • IL6 ST antibody
    • IL6RB_HUMAN antibody
    • IL6ST antibody
    • Interleukin 6 receptor subunit beta antibody
    • Interleukin receptor beta chain antibody
    • Interleukin-6 receptor subunit beta antibody
    • Interleukin-6 signal transducer antibody
    • Membrane glycoprotein 130 antibody
    • Membrane glycoprotein gp130 antibody
    • Oncostatin M receptor antibody
    • Oncostatin M receptor alpha subunit antibody
    • Oncostatin-M receptor subunit alpha antibody
    see all

Anti-CD130 (gp130) antibody [B-R3] 图像

  • Ab47217, staining CD130 (gp130) by Flow Cytometry.

Anti-CD130 (gp130) antibody [B-R3] (ab47217)参考文献

ab47217 has not yet been referenced specifically in any publications.

Product Wall

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"