Anti-CD13抗体[R3-63] (FITC) (ab33486)

概述

  • 产品名称Anti-CD13抗体[R3-63] (FITC)
    参阅全部 CD13 一抗
  • 描述
    大鼠单克隆抗体[R3-63] to CD13 (FITC)
  • 偶联物FITC. Ex: 493nm, Em: 528nm
  • 特异性Recognizes mouse aminopeptidase N (APN), a cell surface protein homologous with human CD13.
  • 经测试应用适用于: Flow Cytmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Intestinal CD13 (Mouse)

  • 常规说明


    In the mouse, CD13 is a non-covalently linked homodimer of approximately 150kD subunits expressed by a variety of cells including monocytes, macrophages, dendritic cell and veiled cells. Clone R3-63 has been reported to block mouse APN enzyme activity.

性能

应用

Our Abpromise guarantee covers the use of ab33486 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt 1/1 - 1/5.

Use 10µl of the suggested working dilution to label 106 cells in 100µl.





ab18446-Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

靶标

  • 功能Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types including small intestinal and tubular epithelial cells, macrophages, granulocytes and synaptic membranes from the CNS. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection.
  • 组织特异性Expressed in epithelial cells of the kidney, intestine, and respiratory tract; granulocytes, monocytes, fibroblasts, endothelial cells, cerebral pericytes at the blood-brain barrier, synaptic membranes of cells in the CNS. Also expressed in endometrial stromal cells, but not in the endometrial glandular cells. Found in the vasculature of tissues that undergo angiogenesis and in malignant gliomas and lymph node metastases from multiple tumor types but not in blood vessels of normal tissues. A soluble form has been found in plasma. It is found to be elevated in plasma and effusions of cancer patients.
  • 序列相似性Belongs to the peptidase M1 family.
  • 结构域Amino acids 260-353 are essential to mediate susceptibility to infection with HCoV-229E (in porcine/human chimeric studies) and more specifically amino acids 288-295 (mutagenesis studies).
  • 翻译后修饰Sulfated.
    N- and O-glycosylated.
    May undergo proteolysis and give rise to a soluble form.
  • 细胞定位Cell membrane. Cytoplasm > cytosol. A soluble form has also been detected.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Alanyl (membrane) aminopeptidase antibody
    • Alanyl aminopeptidase antibody
    • Aminopeptidase M antibody
    • Aminopeptidase N antibody
    • AMPN_HUMAN antibody
    • ANPEP antibody
    • AP M antibody
    • AP N antibody
    • AP-M antibody
    • AP-N antibody
    • APN antibody
    • CD 13 antibody
    • CD13 antibody
    • CD13 antigen antibody
    • gp150 antibody
    • hAPN antibody
    • LAP 1 antibody
    • LAP1 antibody
    • Microsomal aminopeptidase antibody
    • Myeloid plasma membrane glycoprotein CD13 antibody
    • p150 antibody
    • PEPN antibody
    see all

Anti-CD13 antibody [R3-63] (FITC) (ab33486)参考文献

ab33486 has not yet been referenced specifically in any publications.

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