概述

  • 产品名称Anti-CD11c抗体[BU15] (FITC)
    参阅全部 CD11c 一抗
  • 描述
    小鼠单克隆抗体[BU15] to CD11c (FITC)
  • 偶联物FITC. Ex: 493nm, Em: 528nm
  • 特异性This antibody recognises the integrin alphax subunit, a 150kD glycoprotein expressed by macrophages, monocytes, granulocytes and NK cells. The antigen is also expressed by hairy cell leukaemia cells. Ligands for CD11c are ICAM 1, iC3b, and fibrinogen. The molecule has a role in mediating adherence of granulocytes and monocytes to endothelium and fibrinogen.
  • 经测试应用适用于: Flow Cytmore details
  • 种属反应性
    与反应: Dog, Human, Cynomolgus Monkey
  • 免疫原

    The details of the immunogen for this antibody are not available.

性能

应用

Our Abpromise guarantee covers the use of ab22540 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt
  • 应用说明Flow Cyt: Use 10µl of working dilution for 106 cells. Suggested working dilution is neat - 1/10.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.
    • 组织特异性Predominantly expressed in monocytes and granulocytes.
    • 序列相似性Belongs to the integrin alpha chain family.
      Contains 7 FG-GAP repeats.
      Contains 1 VWFA domain.
    • 结构域The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 95 alpha chain antibody
      • 95 antibody
      • CD 11c antibody
      • CD11 antigen-like family member C antibody
      • CD11c antibody
      • CD11c antigen antibody
      • Complement component 3 receptor 4 subunit antibody
      • CR4 antibody
      • Integrin alpha X antibody
      • Integrin alpha X chain antibody
      • Integrin alpha-X antibody
      • Integrin aX antibody
      • Integrin subunit alpha X antibody
      • integrin, alpha X (antigen CD11C (p150), alpha polypeptide) antibody
      • integrin, alpha X (complement component 3 receptor 4 subunit antibody
      • ITAX_HUMAN antibody
      • ITGAX antibody
      • LEU M5 alpha subunit antibody
      • Leu M5 antibody
      • Leukocyte adhesion glycoprotein p150 95 alpha chain antibody
      • Leukocyte adhesion glycoprotein p150 antibody
      • Leukocyte adhesion receptor p150 95 antibody
      • Leukocyte adhesion receptor p150 antibody
      • Leukocyte surface antigen p150 95 alpha subunit antibody
      • Leukocyte surface antigen p150 alpha subunit antibody
      • Myeloid membrane antigen alpha subunit antibody
      • p150 95 integrin alpha chain antibody
      • p150 antibody
      • p150/95 antibody
      • SLEB6 antibody
      see all

    Anti-CD11c antibody [BU15] (FITC) (ab22540)参考文献

    This product has been referenced in:
    • Rezzonico R  et al. Ligation of CD11b and CD11c beta(2) integrins by antibodies or soluble CD23 induces macrophage inflammatory protein 1alpha (MIP-1alpha) and MIP-1beta production in primary human monocytes through a pathway dependent on nuclear factor-kappaB. Blood 97:2932-40 (2001). Read more (PubMed: 11342414) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"