The details of the immunogen for this antibody are not available.
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The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use 0.2µg for 106 cells.
ab154460 - Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
功能Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.
序列相似性Belongs to the integrin alpha chain family. Contains 7 FG-GAP repeats. Contains 1 VWFA domain.
结构域The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
Kamata M et al. ICAM-1 Deficiency Exacerbates Sarcoid-Like Granulomatosis Induced by Propionibacterium acnes through Impaired IL-10 Production by Regulatory T Cells. Am J Pathol183:1731-9 (2013).
Read more (PubMed: 24103557) »
de Groot D et al. Targeted deletion of the inhibitory NF-kappaB p50 subunit in bone marrow-derived cells improves collateral growth after arterial occlusion. Cardiovasc Res88:179-85 (2010).
Read more (PubMed: 20495189) »