PE Anti-CD105抗体[MJ7/18] (ab93567)
Key features and details
- PE Rat monoclonal [MJ7/18] to CD105
- Suitable for: Flow Cyt
- Reacts with: Mouse
- Conjugation: PE. Ex: 488nm, Em: 575nm
- Isotype: IgG2a
Related conjugates and formulations
概述
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产品名称
PE Anti-CD105抗体[MJ7/18]
参阅全部 CD105 一抗 -
描述
PE大鼠单克隆抗体[MJ7/18] to CD105 -
宿主
Rat -
偶联物
PE. Ex: 488nm, Em: 575nm -
经测试应用
适用于: Flow Cytmore details -
种属反应性
与反应: Mouse -
免疫原
Tissue, cells or virus corresponding to Mouse CD105. Inflamed mouse skin
Database link: Q63961 -
阳性对照
- bEnd.3 (Mouse brain endothelioma cell line) whole cell lysate.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. -
存储溶液
pH: 7.20
Preservative: 0.09% Sodium azide
Constituent: PBS -
Concentration information loading...
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纯度
Protein G purified -
克隆
单克隆 -
克隆编号
MJ7/18 -
同种型
IgG2a -
轻链类型
kappa -
研究领域
相关产品
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Alternative Versions
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Compatible Secondaries
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab93567于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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Flow Cyt |
Use 0.25-0.5µg for 105-8 cells.
ab134674 - Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
说明 |
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Flow Cyt
Use 0.25-0.5µg for 105-8 cells. ab134674 - Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
靶标
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功能
Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. -
组织特异性
Endoglin is restricted to endothelial cells in all tissues except bone marrow. -
疾病相关
Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1) [MIM:187300, 108010]; also known as Osler-Rendu-Weber syndrome 1 (ORW1). HHT1 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary (PAVM), cerebral (CAVM) and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia. Although the first symptom of HHT1 in children is generally nose bleed, there is an important clinical heterogeneity. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 13805 Mouse
- SwissProt: Q63961 Mouse
- Unigene: 225297 Mouse
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别名
- AI528660 antibody
- AI662476 antibody
- CD 105 antibody
see all
图片
数据表及文件
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Datasheet download
文献 (7)
ab93567 被引用在 7 文献中.
- Lin S et al. Non-canonical NOTCH3 signalling limits tumour angiogenesis. Nat Commun 8:16074 (2017). PubMed: 28719575
- Yamamoto M et al. Osteogenic Potential of Mouse Adipose-Derived Stem Cells Sorted for CD90 and CD105 In Vitro. Stem Cells Int 2014:576358 (2014). Flow Cyt ; Mouse . PubMed: 25302065
- Wen ST et al. Amniotic fluid stem cells from EGFP transgenic mice attenuate hyperoxia-induced acute lung injury. PLoS One 8:e75383 (2013). PubMed: 24040409
- Pérez-Gómez E et al. A role for endoglin as a suppressor of malignancy during mouse skin carcinogenesis. Cancer Res 67:10268-77 (2007). WB . PubMed: 17974968
- Korpanty G et al. Monitoring response to anticancer therapy by targeting microbubbles to tumor vasculature. Clin Cancer Res 13:323-30 (2007). IHC-Fr . PubMed: 17200371
- Onoe T et al. Liver sinusoidal endothelial cells tolerize T cells across MHC barriers in mice. J Immunol 175:139-46 (2005). IHC-Fr . PubMed: 15972640
- Quintanilla M et al. Expression of the TGF-beta coreceptor endoglin in epidermal keratinocytes and its dual role in multistage mouse skin carcinogenesis. Oncogene 22:5976-85 (2003). WB, IHC-Fr . PubMed: 12955076