概述

  • 产品名称Anti-CD105抗体[4G11]
    参阅全部 CD105 一抗
  • 描述
    小鼠单克隆抗体[4G11] to CD105
  • 经测试应用适用于: IHC-Pmore details
    不适用于: IHC-Fr or WB
  • 种属反应性
    与反应: Human
  • 免疫原

    recombinant protein corresponding to a region of the external domain of human CD105 glycoprotein.

  • 阳性对照
    • Normal human ovary and Tonsil

性能

应用

Our Abpromise guarantee covers the use of ab49679 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
  • 应用说明Is unsuitable for IHC-Fr or WB.
  • 靶标

    • 功能Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors.
    • 组织特异性Endoglin is restricted to endothelial cells in all tissues except bone marrow.
    • 疾病相关Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1) [MIM:187300, 108010]; also known as Osler-Rendu-Weber syndrome 1 (ORW1). HHT1 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary (PAVM), cerebral (CAVM) and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia. Although the first symptom of HHT1 in children is generally nose bleed, there is an important clinical heterogeneity.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • AI528660 antibody
      • AI662476 antibody
      • CD 105 antibody
      • CD105 antibody
      • CD105 antigen antibody
      • EGLN_HUMAN antibody
      • END antibody
      • Endoglin antibody
      • Eng antibody
      • FLJ41744 antibody
      • HHT1 antibody
      • ORW antibody
      • ORW1 antibody
      • Osler Rendu Weber syndrome 1 antibody
      • RP11 228B15.2 antibody
      • S-endoglin antibody
      • SN6 antibody
      see all

    Anti-CD105 antibody [4G11] 图像

    • Normal human ovary: IHC-P staining for endoglin using ab49679. Membrane staining of cells in both the theca interna and theca externa.

    Anti-CD105 antibody [4G11] (ab49679)参考文献

    This product has been referenced in:
    • Smith SJ  et al. Endothelial-like malignant glioma cells in dynamic three dimensional culture identifies a role for VEGF and FGFR in a tumor-derived angiogenic response. Oncotarget 6:22191-205 (2015). IHC ; Human . Read more (PubMed: 26203665) »
    • Pruneri G  et al. Angiogenesis occurs in hairy cell leukaemia (HCL) and in NOD/SCID mice transplanted with the HCL line Bonna-12. Br J Haematol 120:695-8 (2003). Read more (PubMed: 12588359) »

    See all 2 Publications for this product

    Product Wall

    Thank you very much for your calls today and for letting us know about the trouble with ab44967 and these other CD105 antibodies.

    As we discussed, I'm sending a free of charge vial of ab11414 on the order ***, which should arrive tomorrow. Pl...

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    I am sorry this product did not perform as stated on the datasheet and for the inconvenience this has caused. As requested, I have issued a free of charge replacement for one vial of ab49679.

    To check the status of the order please contact o...

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    Thank you for your inquiry.

    I am sorry to hear that your customer is having trouble with these antibodies.

    It seems to me that there must be an issue with the HRP polymer detection system, DAB,or antigen retrieval buffers/system. Th...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"