Anti-CD105抗体[2H6F11], prediluted (CF405M) (ab123634)

概述

  • 产品名称Anti-CD105抗体[2H6F11], prediluted (CF405M)
    参阅全部 CD105 一抗
  • 描述
    小鼠单克隆抗体[2H6F11] to CD105, prediluted (CF405M)
  • 偶联物CF405M. Ex: 408nm, Em: 452nm
  • 经测试应用适用于: ICC/IF, Flow Cytmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Human Endoglin fusion protein.

  • 阳性对照
    • Nalm-6 cell line
  • 常规说明


    CD105 is a component of the TGF-B receptor system and can bind TGF-B1 and TGF-B3 with high affinity but does not bind TGF-B2. CD105 is expressed by vascular endothelial cells and syncytiotrophoblasts of placenta, Pre-B cells in fetal marrow, erythroid precursors in fetal and adult bone marrow and is weakly expressed by stromal fibroblasts. U937 cells and monocytes and tissue macrophages also expresses weakly CD105. Expression of CD105 is increased on activated endothelium in tissues undergoing angiogenesis, such as in tumours, or in cases of wound healing or dermal inflammation.

    CF405M (Abs/Em Max: 408/450nm). Direct replacement for Pacific Blue dye®, BD Horizon™ V450.

性能

应用

Our Abpromise guarantee covers the use of ab123634 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use at an assay dependent concentration.
Flow Cyt Use 5µl for 106 cells. ab126026-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

靶标

  • 功能Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors.
  • 组织特异性Endoglin is restricted to endothelial cells in all tissues except bone marrow.
  • 疾病相关Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1) [MIM:187300, 108010]; also known as Osler-Rendu-Weber syndrome 1 (ORW1). HHT1 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary (PAVM), cerebral (CAVM) and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia. Although the first symptom of HHT1 in children is generally nose bleed, there is an important clinical heterogeneity.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AI528660 antibody
    • AI662476 antibody
    • CD 105 antibody
    • CD105 antibody
    • CD105 antigen antibody
    • EGLN_HUMAN antibody
    • END antibody
    • Endoglin antibody
    • Eng antibody
    • FLJ41744 antibody
    • HHT1 antibody
    • ORW antibody
    • ORW1 antibody
    • Osler Rendu Weber syndrome 1 antibody
    • RP11 228B15.2 antibody
    • S-endoglin antibody
    • SN6 antibody
    see all

Anti-CD105 antibody [2H6F11], prediluted (CF405M) 图像

  • Staining of Nalm-6 cell line with ab123634 at 5 µl/106 cells and isotype control IgG1 CFBlue. Total cells were used for analysis.

Anti-CD105 antibody [2H6F11], prediluted (CF405M) (ab123634)参考文献

ab123634 has not yet been referenced specifically in any publications.

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