Anti-CCRL2抗体[MM0158-5A15] (ab89547)

概述

  • 产品名称Anti-CCRL2抗体[MM0158-5A15]
    参阅全部 CCRL2 一抗
  • 描述
    小鼠单克隆抗体[MM0158-5A15] to CCRL2
  • 特异性ab89547 recognises isoform 1 and 2
  • 经测试应用适用于: Flow Cytmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length Human CCRL2 protein

性能

应用

Our Abpromise guarantee covers the use of ab89547 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt 1/20 - 1/100.

靶标

  • 功能Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses.
  • 组织特异性Expressed abundantly in immunal tissues such as spleen, fetal liver, lymph node and bone marrow. Strong expression also in lung and heart. Expressed in almost all hematopoietic cells including monocytes, macrophages, PMNs, T-cells (both CD4+ and CD8+), monocyte-derived iDCs, NK cells, and CD34+ progenitor cells. B cells expressed isoform 1 but not isoform 2. Up-regulated on synovial neutrophils of rheumatoid arthritis patients.
  • 序列相似性Belongs to the G-protein coupled receptor 1 family.
  • 结构域Lacks the conserved DRYLAIV motif in the second intracellular loop that is required for signaling of functional chemokine receptors.
  • 细胞定位Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • C-C chemokine receptor-like 2 antibody
    • CCRL2 antibody
    • CCRL2_HUMAN antibody
    • Chemokine (C-C motif) receptor like 2 antibody
    • Chemokine receptor CCR11 antibody
    • Chemokine receptor X antibody
    • CKRX antibody
    • CRAM A antibody
    • CRAM B antibody
    • CRAMA antibody
    • CRAMB antibody
    • FLJ55815 antibody
    • HCR antibody
    • MGC116710 antibody
    • MGC34104 antibody
    • Putative MCP 1 chemokine receptor antibody
    • Putative MCP-1 chemokine receptor antibody
    see all

Anti-CCRL2 antibody [MM0158-5A15] (ab89547)参考文献

ab89547 has not yet been referenced specifically in any publications.

Product Wall

Abcam has not validated the combination of species/application used in this Abreview.
Application Flow Cytometry
Sample Dog Cell (from whole blood)
Specification from whole blood
Preparation Cell harvesting/tissue preparation method: after red blood cell lysis
Sample buffer: PBS/BSA 1%
Fixation Paraformaldehyde
Permeabilization No
Gating Strategy alive cells
Username

Abcam user community

Verified customer

提交于 Nov 13 2012

Abcam has not validated the combination of species/application used in this Abreview.
Application Flow Cytometry
Sample Cynomolgus Monkey Cell (Whole blood)
Specification Whole blood
Preparation Cell harvesting/tissue preparation method: After red blood cell lysis
Sample buffer: PBS/BSA 1%/Azide 0.01%
Fixation Paraformaldehyde
Permeabilization No
Gating Strategy alive
Username

Abcam user community

Verified customer

提交于 Apr 27 2012

Thank you for submitting an Abreview of ab89547. As you may have noticed, your review has now been published on our website.
Since you obtained poor results using the antibody in a tested species and application, we would like to follow up on this...

Read More

Thank you for submitting an Abreview of ab89547. As you may have noticed, your review has now been published on our website.
Since you obtained poor results using the antibody in a untested species (mouse), we would like to follow up on this with ...

Read More
Abcam has not validated the combination of species/application used in this Abreview.
Application Flow Cytometry
Sample Mouse Cell (Whole blood)
Specification Whole blood
Preparation Cell harvesting/tissue preparation method: After red blood cell lysis
Sample buffer: PBS/BSA 1%/Azide 0.01%
Fixation Paraformaldehyde
Permeabilization No
Gating Strategy alive lymphocytes
Username

Abcam user community

Verified customer

提交于 Apr 19 2012

Application Flow Cytometry
Sample Human Cell (PBMC)
Specification PBMC
Preparation Cell harvesting/tissue preparation method: from buffy coat after ficoll preparation
Sample buffer: PBS/BSA 1%/Azide 0.01%
Permeabilization No
Gating Strategy alive monocytes
Username

Abcam user community

Verified customer

提交于 Apr 18 2012

Application Flow Cytometry
Sample Rat Cell (Splenocytes)
Specification Splenocytes
Preparation Cell harvesting/tissue preparation method: spleen was mashed
Sample buffer: PBS/BSA 1%/Azide 0.01%
Permeabilization No
Gating Strategy alive macrophages
Username

Abcam user community

Verified customer

提交于 Apr 16 2012

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"