概述

描述

  • 性质Synthetic

技术指标

Our Abpromise guarantee covers the use of ab7876 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    PBS with 0.1% BSA 0.02% sodium azide pH7.2

常规信息

  • 别名
    • AM4 7
    • C C chemokine receptor type 5
    • C C CKR 5
    • C-C chemokine receptor type 5
    • C-C CKR-5
    • C-C motif chemokine receptor 5 A159A
    • CC Chemokine Receptor 5
    • CC Chemokine Receptor Type 5
    • CC CKR 5
    • CC-CKR-5
    • CCCKR 5
    • CCCKR5
    • CCR 5
    • CCR-5
    • CCR5
    • CCR5 chemokine (C C motif) receptor 5
    • CCR5_HUMAN
    • CD 195
    • CD195
    • CD195 Antigen
    • Chemokine C C motif receptor 5
    • Chemokine receptor CCR5
    • CHEMR13
    • CKR 5
    • CKR5
    • CMKBR 5
    • CMKBR5
    • FLJ78003
    • HIV 1 Fusion Coreceptor
    • HIV-1 fusion coreceptor
    • HIV1 fusion coreceptor
    • IDDM22
    • MIP-1 alpha receptor
    see all
  • 功能Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.
  • 组织特异性Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1A and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung.
  • 疾病相关Genetic variation in CCR5 is associated with suseptibility to diabetes mellitus insulin-dependent type 22 (IDDM22) [MIM:612522]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
  • 序列相似性Belongs to the G-protein coupled receptor 1 family.
  • 翻译后修饰Sulfated on at least 2 of the N-terminal tyrosines. Sulfation contributes to the efficiency of HIV-1 entry and is required for efficient binding of the chemokines, CCL3 and CCL4.
    O-glycosylated, but not N-glycosylated. Ser-6 appears to be the major site. Also sialylated glycans present which contribute to chemokine binding. Thr-16 and Ser-17 may also be glycosylated and, if so, with small moieties such as a T-antigen.
    Palmitoylation in the C-terminal is important for cell surface expression, and to a lesser extent, for HIV entry.
    Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES.
  • 细胞定位Cell membrane.
  • Information by UniProt

CCR5 peptide (ab7876)参考文献

ab7876 has not yet been referenced specifically in any publications.

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These peptides are very short fragments of the CCR5 protein and as such may not contain the gp120 binding site. You may wish to use the whole protein. While this is not currently available at Abcam...

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Happy New Year! Thank you for your enquiry. The predicted MW for ab7876: CCR5 peptide is 1.75 kDa. I hope this helps and if I can assist further, please do not hesitate to contact me.

As far as we are aware, this peptide has not been tested in this application

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"