PE Anti-CCR5抗体[HM-CCR5(7A4)] (ab95662)
Key features and details
- PE Armenian hamster monoclonal [HM-CCR5(7A4)] to CCR5
- Suitable for: Flow Cyt
- Reacts with: Mouse
- Conjugation: PE. Ex: 488nm, Em: 575nm
- Isotype: IgG
概述
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产品名称
PE Anti-CCR5抗体[HM-CCR5(7A4)]
参阅全部 CCR5 一抗 -
描述
PE亚美尼亚仓鼠单克隆抗体[HM-CCR5(7A4)] to CCR5 -
宿主
Armenian hamster -
偶联物
PE. Ex: 488nm, Em: 575nm -
特异性
Binds to the N terminal extracellular domain of Mouse CCR5 with no cross reactivity to Human CCR5. -
经测试应用
适用于: Flow Cytmore details -
种属反应性
与反应: Mouse
不与反应: Human -
免疫原
Full length protein corresponding to Mouse CCR5. Native protein
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阳性对照
- Mouse thioglycolate-elicited peritoneal-exudate cells
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. -
存储溶液
pH: 7.20
Preservative: 0.09% Sodium azide
Constituent: PBS -
Concentration information loading...
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纯度
Protein G purified -
克隆
单克隆 -
克隆编号
HM-CCR5(7A4) -
同种型
IgG -
研究领域
相关产品
-
Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab95662于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
Flow Cyt |
Use 0.5-1µg for 105-8 cells.
in a final volume of 100 µL
ab101026 - Armenian Hamster monoclonal IgG, is suitable for use as an isotype control with this antibody.
|
说明 |
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Flow Cyt
Use 0.5-1µg for 105-8 cells. in a final volume of 100 µL
ab101026 - Armenian Hamster monoclonal IgG, is suitable for use as an isotype control with this antibody.
|
靶标
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功能
Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates. -
组织特异性
Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1A and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung. -
疾病相关
Genetic variation in CCR5 is associated with suseptibility to diabetes mellitus insulin-dependent type 22 (IDDM22) [MIM:612522]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. -
序列相似性
Belongs to the G-protein coupled receptor 1 family. -
翻译后修饰
Sulfated on at least 2 of the N-terminal tyrosines. Sulfation contributes to the efficiency of HIV-1 entry and is required for efficient binding of the chemokines, CCL3 and CCL4.
O-glycosylated, but not N-glycosylated. Ser-6 appears to be the major site. Also sialylated glycans present which contribute to chemokine binding. Thr-16 and Ser-17 may also be glycosylated and, if so, with small moieties such as a T-antigen.
Palmitoylation in the C-terminal is important for cell surface expression, and to a lesser extent, for HIV entry.
Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES. -
细胞定位
Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 12774 Mouse
- SwissProt: P51682 Mouse
- Unigene: 14302 Mouse
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别名
- AM4 7 antibody
- C C chemokine receptor type 5 antibody
- C C CKR 5 antibody
see all
图片
数据表及文件
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Datasheet download
文献 (0)
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