Anti-CCR5抗体[HM-CCR5 (7A4)] (Biotin) (ab95663)

概述

  • 产品名称Anti-CCR5抗体[HM-CCR5 (7A4)] (Biotin)
    参阅全部 CCR5 一抗
  • 描述
    亚美尼亚仓鼠单克隆抗体[HM-CCR5 (7A4)] to CCR5 (Biotin)
  • 偶联物Biotin
  • 特异性ab95663 binds the N terminal extracellular domain of Mouse CCR5 with no crossreactivity to Human CCR5.
  • 经测试应用适用于: Flow Cytmore details
  • 种属反应性
    与反应: Mouse
    不与反应: Human
  • 免疫原

    Full length Mouse CCR5

  • 阳性对照
    • FcR-blocked (Anti-Mouse CD16/CD32 Purified) BALB/c peritoneal exudate cells; Mouse thioglycolate elicited peritoneal cells (PECS).

性能

应用

Our Abpromise guarantee covers the use of ab95663 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use 0.25-0.5µg for 105-8 cells. Staining the cell sample in a final volume of 100 µl is recommended.

靶标

  • 功能Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.
  • 组织特异性Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1A and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung.
  • 疾病相关Genetic variation in CCR5 is associated with suseptibility to diabetes mellitus insulin-dependent type 22 (IDDM22) [MIM:612522]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
  • 序列相似性Belongs to the G-protein coupled receptor 1 family.
  • 翻译后修饰Sulfated on at least 2 of the N-terminal tyrosines. Sulfation contributes to the efficiency of HIV-1 entry and is required for efficient binding of the chemokines, CCL3 and CCL4.
    O-glycosylated, but not N-glycosylated. Ser-6 appears to be the major site. Also sialylated glycans present which contribute to chemokine binding. Thr-16 and Ser-17 may also be glycosylated and, if so, with small moieties such as a T-antigen.
    Palmitoylation in the C-terminal is important for cell surface expression, and to a lesser extent, for HIV entry.
    Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES.
  • 细胞定位Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AM4 7 antibody
    • C C chemokine receptor type 5 antibody
    • C C CKR 5 antibody
    • C-C chemokine receptor type 5 antibody
    • C-C CKR-5 antibody
    • C-C motif chemokine receptor 5 A159A antibody
    • CC Chemokine Receptor 5 antibody
    • CC Chemokine Receptor Type 5 antibody
    • CC CKR 5 antibody
    • CC-CKR-5 antibody
    • CCCKR 5 antibody
    • CCCKR5 antibody
    • CCR 5 antibody
    • CCR-5 antibody
    • CCR5 antibody
    • CCR5 chemokine (C C motif) receptor 5 antibody
    • CCR5_HUMAN antibody
    • CD 195 antibody
    • CD195 antibody
    • CD195 Antigen antibody
    • Chemokine C C motif receptor 5 antibody
    • Chemokine receptor CCR5 antibody
    • CHEMR13 antibody
    • CKR 5 antibody
    • CKR5 antibody
    • CMKBR 5 antibody
    • CMKBR5 antibody
    • FLJ78003 antibody
    • HIV 1 Fusion Coreceptor antibody
    • HIV-1 fusion coreceptor antibody
    • HIV1 fusion coreceptor antibody
    • IDDM22 antibody
    • MIP-1 alpha receptor antibody
    see all

Anti-CCR5 antibody [HM-CCR5 (7A4)] (Biotin) 图像

  • Flow cytometry staining of FcR-blocked (Anti-Mouse CD16/CD32 Purified) BALB/c peritoneal exudate cells with Anti-Mouse CD11b FITC and 0.25 µg of Armenian Hamster IgG Isotype Control Biotin (left) or 0.25 µg of ab95663 (right) followed by Streptavidin PE. Total viable cells were used for analysis.

Anti-CCR5 antibody [HM-CCR5 (7A4)] (Biotin) (ab95663)参考文献

ab95663 has not yet been referenced specifically in any publications.

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