概述

  • 产品名称Anti-CCNL1抗体
    参阅全部 CCNL1 一抗
  • 描述
    兔多克隆抗体to CCNL1
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow
  • 免疫原

    A region within a synthetic peptide: TGGILIGDRL YSEVSLTIDH SLIPEERLSP TPSMQDGLDL PSETDLRILG, corresponding to N terminal amino acids 37-86 of Human CCNL1

  • 阳性对照
    • HepG2 cell lysate

性能

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应用

Our Abpromise guarantee covers the use of ab26253 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 2.5 µg/ml. Detects a band of approximately 57 kDa (predicted molecular weight: 60 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA 1/62500.

靶标

  • 功能Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21.
  • 组织特异性Ubiquitous with higher level in thymus. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC).
  • 序列相似性Belongs to the cyclin family. Cyclin L subfamily.
  • 结构域Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions.
  • 细胞定位Nucleus speckle. More specifically found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Ania 6a antibody
    • CCNL1 antibody
    • CCNL1_HUMAN antibody
    • Cyclin L antibody
    • Cyclin L gamma antibody
    • Cyclin L1 antibody
    • Cyclin-L antibody
    • Cyclin-L1 antibody
    see all

Anti-CCNL1 antibody 图像

Anti-CCNL1 antibody (ab26253)参考文献

ab26253 has not yet been referenced specifically in any publications.

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