概述

  • 产品名称Anti-CCNL1抗体
    参阅全部 CCNL1 一抗
  • 描述
    兔多克隆抗体to CCNL1
  • 经测试应用适用于: WB, IP, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Chicken, Dog
  • 免疫原

    Synthetic peptide: KLKAKGLNPD GTPALSTLGG FSPASKPSSP REVKAEEKSP ISINVKTVKK EPEDRQ, corresponding to amino acids 314-369 of Human Cyclin L1a

  • 阳性对照
    • Human thymus tissue

性能

应用

Our Abpromise guarantee covers the use of ab118957 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/2000 - 1/5000. Predicted molecular weight: 60 kDa.
IP Use at an assay dependent concentration.
ELISA 1/5000 - 1/25000.
IHC-P Use a concentration of 10 - 20 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21.
  • 组织特异性Ubiquitous with higher level in thymus. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC).
  • 序列相似性Belongs to the cyclin family. Cyclin L subfamily.
  • 结构域Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions.
  • 细胞定位Nucleus speckle. More specifically found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Ania 6a antibody
    • CCNL1 antibody
    • CCNL1_HUMAN antibody
    • Cyclin L antibody
    • Cyclin L gamma antibody
    • Cyclin L1 antibody
    • Cyclin-L antibody
    • Cyclin-L1 antibody
    see all

Anti-CCNL1 antibody 图像

  • ab118957 at 20µg/ml staining paraffin embedded formalin fixed CCNL1 in Human thymus tissue by immunohistochemistry. Following primary incubation slides were incubated with biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-CCNL1 antibody (ab118957)参考文献

ab118957 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab118957.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"