概述

  • 产品名称Anti-CCM2抗体
    参阅全部 CCM2 一抗
  • 描述
    小鼠多克隆抗体to CCM2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length Human CCM2 protein (NP_113631.1).

  • 阳性对照
    • Human placenta tissue lysate. Cell lysate from transfected 293T cells.

性能

应用

Our Abpromise guarantee covers the use of ab88835 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 49 kDa.

靶标

  • 功能May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock.
  • 疾病相关Defects in CCM2 are the cause of cerebral cavernous malformations type 2 (CCM2) [MIM:603284]. Cerebral cavernous malformations (CCMs) are congenital vascular anomalies of the central nervous system that can result in hemorrhagic stroke, seizures, recurrent headaches, and focal neurologic deficits. CCMs have an incidence of 0.1%-0.5% in the general population and are usually present clinically during the 3rd to 5th decades of life. The lesions are characterized by grossly enlarged blood vessels consisting of a single layer of endothelium and without any intervening neural tissue, ranging in diameter from a few millimeters to several centimeters.
  • 序列相似性Contains 1 PID domain.
  • 细胞定位Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • C7orf22 antibody
    • Ccm2 antibody
    • CCM2 gene antibody
    • CCM2_HUMAN antibody
    • Cerebral cavernous malformation 2 antibody
    • Cerebral cavernous malformations 2 protein antibody
    • Chromosome 7 open reading frame 22 antibody
    • Malcavernin antibody
    • MGC4067 antibody
    • MGC4607 antibody
    • MGC74868 antibody
    • OSM antibody
    • Osmosensing scaffold for MEKK3 antibody
    • OTTHUMP00000159554 antibody
    • OTTHUMP00000214270 antibody
    • OTTHUMP00000214271 antibody
    • OTTHUMP00000214273 antibody
    • PP10187 antibody
    see all

Anti-CCM2 antibody 图像

  • Anti-CCM2 antibody (ab88835) at 1 µg/ml + Human placenta tissue lysate at 50 µg

    Predicted band size : 49 kDa
    Observed band size : 49 kDa
  • All lanes : Anti-CCM2 antibody (ab88835) at 1 µg/ml

    Lane 1 : cell lysate from CCM2 transfected 293T cell lysate
    Lane 2 : cell lysate from non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 49 kDa
    Observed band size : ~60 kDa (why is the actual band size different from the predicted?)

Anti-CCM2 antibody (ab88835)参考文献

ab88835 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab88835.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"