概述

  • 产品名称Anti-CCM2抗体
    参阅全部 CCM2 一抗
  • 描述
    山羊多克隆抗体to CCM2
  • 特异性This antibody is expected to recognize both reported isoforms (NP_001025006.1 and NP_113631.1).
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow, Dog
  • 免疫原

    Synthetic peptide:

    C-KGEKSRDKKAHEK

    , corresponding to internal sequence amino acids 23-35 of Human CCM2

  • 阳性对照
    • Human heart lysate.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris saline, pH 7.3
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

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应用

Our Abpromise guarantee covers the use of ab53557 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明Peptide ELISA: antibody detection limit dilution 1:128,000.

    WB: Use at a concentration of 0.03 - 0.1 µg/ml. Detects a band of approximately 49 kDa (predicted molecular weight: 49 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock.
    • 疾病相关Defects in CCM2 are the cause of cerebral cavernous malformations type 2 (CCM2) [MIM:603284]. Cerebral cavernous malformations (CCMs) are congenital vascular anomalies of the central nervous system that can result in hemorrhagic stroke, seizures, recurrent headaches, and focal neurologic deficits. CCMs have an incidence of 0.1%-0.5% in the general population and are usually present clinically during the 3rd to 5th decades of life. The lesions are characterized by grossly enlarged blood vessels consisting of a single layer of endothelium and without any intervening neural tissue, ranging in diameter from a few millimeters to several centimeters.
    • 序列相似性Contains 1 PID domain.
    • 细胞定位Cytoplasm.
    • Information by UniProt
    • 数据库链接
    • 别名
      • C7orf22 antibody
      • Ccm2 antibody
      • CCM2 gene antibody
      • CCM2_HUMAN antibody
      • Cerebral cavernous malformation 2 antibody
      • Cerebral cavernous malformations 2 protein antibody
      • Chromosome 7 open reading frame 22 antibody
      • Malcavernin antibody
      • MGC4067 antibody
      • MGC4607 antibody
      • MGC74868 antibody
      • OSM antibody
      • Osmosensing scaffold for MEKK3 antibody
      • OTTHUMP00000159554 antibody
      • OTTHUMP00000214270 antibody
      • OTTHUMP00000214271 antibody
      • OTTHUMP00000214273 antibody
      • PP10187 antibody
      see all

    Anti-CCM2 antibody 图像

    • Anti-CCM2 antibody (ab53557) at 0.03 µg/ml + Human Heart lysate (35µg protein in RIPA buffer)

      Predicted band size : 49 kDa
      Observed band size : 49 kDa

    Anti-CCM2 antibody (ab53557)参考文献

    ab53557 has not yet been referenced specifically in any publications.

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