概述

  • 产品名称Anti-CCKAR抗体
    参阅全部 CCKAR 一抗
  • 描述
    兔多克隆抗体to CCKAR
  • 经测试应用适用于: ICC, IHC-P, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Dog
  • 免疫原

    Synthetic peptide:

    TGASLSRFSYSHMSASVPPQ

    conjugated to KLH, corresponding to amino acids 409-428 of Human CCKAR

  • 阳性对照
    • HEK293 cells that have been transfected to express CCK1.

性能

应用

Our Abpromise guarantee covers the use of ab28627 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC 1/1000.
IHC-P 1/500.
WB 1/1000. Detects a band of approximately 80-90 kDa.

靶标

  • 相关性The cholecystokinin (CCK) family of peptide hormones have been implicated in numerous important physiologic events. These appear to be mediated through 2 general classes of receptors, A (CCKAR)and B (CCKBR), based on their binding affinities for CCK/gastrin family peptides. Through binding to class A receptors, CCK is a major physiologic mediator of gallbladder contraction and pancreatic enzyme secretion. It appears to play a role in slowing gastric emptying, relaxation of the sphincter of Oddi, and potentiation of insulin secretion. Further, it has been implicated as a mediator of pancreatic growth and tumorigenesis. Class A receptors have also been described in the anterior pituitary, myenteric plexus, and regions of the central nervous system, where they have been implicated in the pathogenesis of feeding disorders, Parkinson disease, schizophrenia, and drug addiction.
  • 细胞定位Integral membrane protein
  • 数据库链接
  • 别名
    • CCK A antibody
    • CCK A receptor antibody
    • CCK AR antibody
    • CCK-A receptor antibody
    • CCK1 R antibody
    • CCK1-R antibody
    • CCK1R antibody
    • CCKA antibody
    • CCKA receptor antibody
    • CCKR Type A antibody
    • CCKRA antibody
    • Cholecystokinin 1 receptor antibody
    • Cholecystokinin A receptor antibody
    • Cholecystokinin receptor type A antibody
    • Cholecystokinin type A receptor antibody
    see all

Anti-CCKAR antibody 图像

  • ab28627 staining Human CCKAR in Human gastric mucosa by immunohistochemistry using paraffin embedded tissue.

Anti-CCKAR antibody (ab28627)参考文献

This product has been referenced in:
  • Gonzalez-Coto AF  et al. Expression of cholecystokinin, gastrin, and their receptors in the mouse cornea. Invest Ophthalmol Vis Sci 55:1965-75 (2014). Mouse . Read more (PubMed: 24576871) »

See 1 Publication for this product

Product Wall

Thank you for your enquiry. I am sorry we do not supply this peptide as one of our products. The sequence of the immunogen used is TGASLSRFSYSHMSASVPPQ. I hope this has helped. Please do get back to me if you have any more queries. With thanks.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"