概述

  • 产品名称Anti-CCDC98抗体
    参阅全部 CCDC98 一抗
  • 描述
    兔多克隆抗体to CCDC98
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rhesus monkey, Orangutan
  • 免疫原

    Synthetic peptide, corresponding to a region within amino acids 400-409 of Human CCDC98 (NP_620775.2)

  • 阳性对照
    • Human Ovarian Carcinoma and Testicular Seminoma tissue.

性能

应用

Our Abpromise guarantee covers the use of ab113278 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.

靶标

  • 功能Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1.
  • 序列相似性Belongs to the FAM175 family. Abraxas subfamily.
  • 结构域The MPN-like region is similar to the MPN (JAB/Mov34) domain. Its presence reveals similarities between the structure of the 19S proteasome and the BRCA1-A complexes.
  • 翻译后修饰Phosphorylation of Ser-406 of the pSXXF motif by ATM or ATR constitutes a specific recognition motif for the BRCT domain of BRCA1. Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Nucleus. Localizes at sites of DNA damage at double-strand breaks.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 3830405G04Rik antibody
    • 5630400M01Rik antibody
    • ABRA1 antibody
    • ABRAXAS antibody
    • Abraxas protein antibody
    • AI506069 antibody
    • AL024423 antibody
    • AV118690 antibody
    • BRCA1-A complex subunit Abraxas antibody
    • coiled coil domain containing 98 antibody
    • Coiled-coil domain-containing protein 98 antibody
    • F175A_HUMAN antibody
    • FAM175A antibody
    • Family with sequence similarity 175 member A antibody
    • FLJ11520 antibody
    • FLJ12642 antibody
    • FLJ13614 antibody
    • Protein FAM175A antibody
    see all

Anti-CCDC98 antibody 图像

  • Detection of Human CCDC98 by Immunohistochemistry.
    Sample: FFPE section of Human ovarian carcinoma. ab113278 used at a dilution of 1/250. Detection: DAB staining.

Anti-CCDC98 antibody (ab113278)参考文献

ab113278 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab113278.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"