The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
应用说明WB: 1/500 - 1/1000. Detects a band of approximately 27 kDa (predicted molecular weight for isoform 3: 23 kDa).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
功能Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis.
组织特异性Not expressed in blood or lymphatic endothelial cells.
疾病相关Defects in CCBE1 are the cause of Hennekam lymphangiectasia-lymphedema syndrome (HLYLMP) [MIM:235510]. HLYLMP is a generalized lymph-vessels dysplasia characterized by intestinal lymphangiectasia with severe lymphedema of the limbs, genitalia and face. In addition, affected individuals have unusual facies and severe mental retardation.
序列相似性Belongs to the CCBE1 family. Contains 2 collagen-like domains. Contains 1 EGF-like domain.