The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 2 - 5 µg/ml. Predicted molecular weight: 44 kDa.
Use a concentration of 2 - 10 µg/ml.
功能Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis.
组织特异性Not expressed in blood or lymphatic endothelial cells.
疾病相关Defects in CCBE1 are the cause of Hennekam lymphangiectasia-lymphedema syndrome (HLYLMP) [MIM:235510]. HLYLMP is a generalized lymph-vessels dysplasia characterized by intestinal lymphangiectasia with severe lymphedema of the limbs, genitalia and face. In addition, affected individuals have unusual facies and severe mental retardation.
序列相似性Belongs to the CCBE1 family. Contains 2 collagen-like domains. Contains 1 EGF-like domain.
Immunofluorescent images showing Human foreskin (left hand image) and negative control of a consecutive section (right hand image), stained with ab111495 at a 1/50 dilution. Epidermial and scattered cells in the dermis are stained green (left hand image), whereas nuclei are counter-stained blue (right hand image: negative control of a consecutive section).
Anti-CCBE1 antibody (ab111495)参考文献
has not yet been referenced specifically in any publications.