概述

  • 产品名称Anti-CC2D1A抗体
    参阅全部 CC2D1A 一抗
  • 描述
    小鼠多克隆抗体to CC2D1A
  • 特异性This antibody is reactive against mammalian transfected lysate.
  • 经测试应用适用于: ICC/IF, IHC-P, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    CC2D1A (NP_060191, 1 a.a. ~ 951 a.a) full-length human protein.

  • 阳性对照
    • CC2D1A transfected 293T cell lysate and human liver tissue lysate

性能

应用

Our Abpromise guarantee covers the use of ab68302 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use a concentration of 10 µg/ml.
IHC-P Use a concentration of 3 µg/ml.
WB 1/500 - 1/1000. Detects a band of approximately 104 to 125 kDa (predicted molecular weight: 104 kDa).

靶标

  • 相关性CC2D1A belongs to the CC2D1 family. It contains one C2 domain. It is a transcription factor that binds specifically to the FRE (five repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. CC2D1A may play a role in the altered regulation of HTR1A associated with anxiety and major depression. It also mediates HDAC-independent repression of HTR1A promoter in neuronal cell. There are three named isoforms. Defects in CC2D1A are the cause of non-syndromic mental retardation autosomal recessive type 3 (MRT3). Patients display severe mental retardation and psychomotor development delay in early childhood. Non-syndromic mental retardation patients do not manifest other clinical signs.
  • 细胞定位Cytoplasm. Nucleus.
  • 数据库链接
  • 别名
    • Akt kinase interacting protein 1 antibody
    • Coiled coil and C2 domain containing 1A antibody
    • Coiled coil and C2 domain containing protein 1A antibody
    • Five repressor element under dual repression binding protein 1 antibody
    • FLJ20241 antibody
    • FLJ41160 antibody
    • FRE under dual repression binding protein 1 antibody
    • FREUD 1 antibody
    • Freud 1/Aki1 antibody
    • Mental retardation, nonsyndromic, autosomal recessive, 3 antibody
    • MRT3 antibody
    • Putative NF kappa B activating protein 023N antibody
    • Putative NF kappa B activating protein antibody
    see all

Anti-CC2D1A antibody 图像

  • Anti-CC2D1A antibody (ab68302) at 1/500 dilution + human liver tissue lysate at 25 µg

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 104 kDa
    Observed band size : 125 kDa (why is the actual band size different from the predicted?)
  • All lanes : Anti-CC2D1A antibody (ab68302) at 1/500 dilution

    Lane 1 : CC2D1A transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 104 kDa
    Observed band size : 104 kDa
    Additional bands at : 125 kDa. We are unsure as to the identity of these extra bands.
  • Immunofluorescence of ab68302 staining on HeLa cell at a concentration of 10 ug/ml.
  • Immunoperoxidase of ab68302 on formalin-fixed paraffin-embedded human small intestine. Antibody concentration, 3 ug/ml.

Anti-CC2D1A antibody (ab68302)参考文献

This product has been referenced in:
  • Manzini MC  et al. CC2D1A regulates human intellectual and social function as well as NF-?B signaling homeostasis. Cell Rep 8:647-55 (2014). WB ; Human . Read more (PubMed: 25066123) »

See 1 Publication for this product

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