概述

  • 产品名称Anti-cbx7抗体
    参阅全部 cbx7 一抗
  • 描述
    小鼠多克隆抗体to cbx7
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length Human cbx7 (NP_783640.1, amino acids 1-251)

  • 阳性对照
    • HeLa nuclear extract, cbx7 transfected 293T cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab89637 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 28 kDa.

靶标

  • 相关性Control of cell proliferation by Polycomb group proteins (PcG) is an important facet of cellular homeostasis and its disruption can promote tumorigenesis. CBX7 is a novel PcG protein which is found to control the growth of normal cells. CBX7 is a gene that encodes a Polycomb protein, as shown by sequence homology, its interaction with Ring1 and its localization to nuclear Polycomb bodies. CBX7 extends the lifespan of a wide range of normal human cells and immortalizes mouse fibroblasts by downregulating expression of the Ink4a/Arf locus. CBX7 does not inter-function or colocalize with Bmi1, and both can exert their actions independently of each other as shown by reverse genetics. CBX7 was highly expressed in three different prostate cancer cell lines and present at elevated levels in normal prostate. (Gil et al., 2004).
  • 细胞定位Nuclear
  • 数据库链接
  • 别名
    • Cbx 7 antibody
    • CBX7 antibody
    • Chromobox homolog 7 antibody
    • Chromobox protein homolog 7 antibody

Anti-cbx7 antibody 图像

Anti-cbx7 antibody (ab89637)参考文献

ab89637 has not yet been referenced specifically in any publications.

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