概述

  • 产品名称Anti-cbx2抗体
    参阅全部 CBX2 一抗
  • 描述
    小鼠单克隆抗体to cbx2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: EVQNRKRGKR PRGRPRKLTA MSSCSRRSKL KVGGCAGYAD PTSQHPLGVG GRQREGLGPS GRGWHFCQQS VPLLGKQEPP FFLSLSFCCQ GPQPAESSSP , corresponding to amino acids 66-166 of Human cbx2

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • 纯度Protein G purified
  • 克隆单克隆
  • 同种型IgG2a
  • 轻链类型kappa
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab57890 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Involved in sexual development, acting as activator of NR5A1 expression.
    • 疾病相关Defects in CBX2 are the cause of 46,XY sex reversal type 5 (SRXY5) [MIM:613080]. It is a disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females.
    • 序列相似性Contains 1 A.T hook DNA-binding domain.
      Contains 1 chromo domain.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Cbx 2 antibody
      • CBX2 antibody
      • CBX2_HUMAN antibody
      • CDC A6 antibody
      • CDCA6 antibody
      • Cell division cycle associated 6 antibody
      • Cell division cycle associated6 antibody
      • chromobox homolog 2 (Pc class homolog, Drosophila) antibody
      • Chromobox homolog 2 antibody
      • Chromobox homolog2 antibody
      • Chromobox protein homolog 2 antibody
      • hromobox homolog 2 antibody
      • M33 antibody
      • M33 polycomb like antibody
      • MOD 2 antibody
      • MOD2 antibody
      • Modifier 3 antibody
      • Modifier3 antibody
      • Pc class homolog antibody
      • Polycomb antibody
      • SRXY5 antibody
      see all

    Anti-cbx2 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab57890 cbx2 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    Anti-cbx2 antibody (ab57890)参考文献

    ab57890 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab57890.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"