概述

  • 产品名称Anti-CBLN1抗体
    参阅全部 CBLN1 一抗
  • 描述
    兔多克隆抗体to CBLN1
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to Human CBLN1 (internal sequence). A 15 amino acid synthetic peptide from the middle of human CBLN1.

  • 阳性对照
    • Human prostate tissue.

性能

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应用

Our Abpromise guarantee covers the use of ab64184 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 2 - 4 µg/ml. Predicted molecular weight: 21 kDa.
IHC-P Use a concentration of 10 µg/ml.

靶标

  • 功能Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the formation and maintenance of parallel fiber and Purkinje cell synapses. When parallel fibers make contact with Purkinje spines, CBLN1 interaction with GRID2 triggers the recruitment of NRXN1 and secretory vesicles to the sites of contact. NRXN1-CBLN1-GRID2 signaling induces presynaptic morphological changes, which may further accumulate pre- and postsynaptic components to promote bidirectional maturation of parallel fiber - Purkinje cell functionnally active synapses by a positive feedback mechanism. Required for CBLN3 export from the endoplasmic reticulum and secretion.
    The cerebellin peptide exerts neuromodulatory functions. Directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release.
  • 组织特异性In the Purkinje cells postsynaptic structures. In the cerebellum, cerebellin is much less abundant than [des-Ser1]-cerebellin.
  • 序列相似性Contains 1 C1q domain.
  • 发展阶段Low at birth, the cerebellin concentration increases between day 5 and 15, and reaches peak values between day 21 and 56.
  • 翻译后修饰The proteolytic processing to yield cerebellin seems to occur either prior to the secretion by presynaptic neurons and subsequent oligomerization or in some other location after release of the mature protein.
  • 细胞定位Secreted. Cell junction > synapse > postsynaptic cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • [des-Ser1]-cerebellin antibody
    • CBLN 1 antibody
    • CBLN1 antibody
    • CBLN1_HUMAN antibody
    • CER antibody
    • Cerebellin 1 antibody
    • Cerebellin 1 precursor antibody
    • Cerebellin1 antibody
    • Precerebellin antibody
    see all

Anti-CBLN1 antibody 图像

  • ab64184 (10ug/ml) staining human CBLN1 in human prostate tissue by immunohistochemistry using formalin-fixed, paraffin-embedded tissue.

Anti-CBLN1 antibody (ab64184)参考文献

This product has been referenced in:
  • Muguruma K  et al. Ontogeny-recapitulating generation and tissue integration of ES cell-derived Purkinje cells. Nat Neurosci 13:1171-80 (2010). Mouse . Read more (PubMed: 20835252) »

See 1 Publication for this product

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In answer to your questions:

1. Regarding ab36909 Precerebellin antibody

Based on the immunogen sequence, this antibody should detect precerebellin and cerebellin-1 (precerebellin without the...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"