Anti-CBL (phospho Y700)抗体(ab63512)


  • 产品名称Anti-CBL (phospho Y700)抗体
    参阅全部 CBL 一抗
  • 描述
    兔多克隆抗体to CBL (phospho Y700)
  • 特异性ab63512 detects endogenous levels of CBL only when phosphorylated at tyrosine 700.
  • 经测试应用适用于: ICC/IF, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthesized phosphopeptide derived from human CBL around the phosphorylation site of tyrosine 700 (TEYpMT).

  • 阳性对照
    • HepG2 cells



Our Abpromise guarantee covers the use of ab63512 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF 1/100 - 1/500.
ELISA 1/10000.


  • 功能Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.
  • 通路Protein modification; protein ubiquitination.
  • 疾病相关Defects in CBL are the cause of Noonan syndrome-like disorder (NSL) [MIM:613563]. NSL is a syndrome characterized by a phenotype reminiscent of Noonan syndrome. Clinical features are highly variable, including facial dysmorphism, short neck, developmental delay, hyperextensible joints and thorax abnormalities with widely spaced nipples. The facial features consist of triangular face with hypertelorism, large low-set ears, ptosis, and flat nasal bridge. Some patients manifest cardiac defects.
  • 序列相似性Contains 1 Cbl-PTB (Cbl-type phosphotyrosine-binding) domain.
    Contains 1 RING-type zinc finger.
    Contains 1 UBA domain.
  • 结构域The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.
    The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.
  • 翻译后修饰Phosphorylated on tyrosine residues by EGFR, SYK, FYN and ZAP70 (By similarity). Phosphorylated on tyrosine residues by INSR.
  • 细胞定位Cytoplasm.
  • Information by UniProt
  • 数据库链接
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Anti-CBL (phospho Y700) antibody 图像

  • ab63512, used at a dilution of 1/100, staining HepG2 cells by immunofluoresence in the absence (1) and presence (2) of the phosphopeptide.

Anti-CBL (phospho Y700) antibody (ab63512)参考文献

ab63512 has not yet been referenced specifically in any publications.

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