Anti-CBFb抗体[EPR6321] (ab124693)


  • 产品名称Anti-CBFb抗体[EPR6321]
    参阅全部 CBFb 一抗
  • 描述
    兔单克隆抗体[EPR6321] to CBFb
  • 经测试应用适用于: WB, ICCmore details
    不适用于: Flow Cyt,IHC-P or IP
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide, corresponding to residues from Human CBFb.

  • 阳性对照
    • K562, Jurkat and HUVEC cell lysates.
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.



Our Abpromise guarantee covers the use of ab124693 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Detects a band of approximately 22 kDa (predicted molecular weight: 22 kDa).
ICC 1/100 - 1/250.
  • 应用说明Is unsuitable for Flow Cyt,IHC-P or IP.
  • 靶标

    • 功能CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBFB enhances DNA binding by RUNX1.
    • 疾病相关Note=A chromosomal aberration involving CBFB is associated with acute myeloid leukemia of M4EO subtype. Pericentric inversion inv(16)(p13;q22). The inversion produces a fusion protein that consists of the 165 N-terminal residues of CBF-beta (PEPB2) with the tail region of MYH11.
    • 序列相似性Belongs to the CBF-beta family.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CBF b antibody
      • CBF beta antibody
      • CBF-beta antibody
      • CBFB antibody
      • CBFbeta antibody
      • Core binding factor beta subunit antibody
      • core binding factor subunit beta antibody
      • Core-binding factor subunit beta antibody
      • PEA 2 antibody
      • PEA2 antibody
      • PEA2 beta antibody
      • PEA2-beta antibody
      • PEA2beta antibody
      • PEBB_HUMAN antibody
      • PEBP 2B antibody
      • PEBP2 beta antibody
      • PEBP2-beta antibody
      • PEBP2B antibody
      • PEBP2beta antibody
      • Polyomavirus enhancer binding protein 2 beta subunit antibody
      • Polyomavirus enhancer-binding protein 2 beta subunit antibody
      • SL3 3 enhancer factor 1 beta subunit antibody
      • SL3 3 enhancer factor 1 subunit beta antibody
      • SL3-3 enhancer factor 1 subunit beta antibody
      • SL3/AKV core binding factor beta subunit antibody
      • SL3/AKV core-binding factor beta subunit antibody
      see all

    Anti-CBFb antibody [EPR6321] 图像

    • All lanes : Anti-CBFb antibody [EPR6321] (ab124693) at 1/1000 dilution

      Lane 1 : K562 cell lysate
      Lane 2 : Jurkat cell lysate
      Lane 3 : HUVEC cell lysate

      Lysates/proteins at 10 µg per lane.

      Goat anti-Rabbit HRP at 1/2000 dilution

      Predicted band size : 22 kDa
    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    Anti-CBFb antibody [EPR6321] (ab124693)参考文献

    ab124693 has not yet been referenced specifically in any publications.

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