Anti-CBFb抗体(ab125191)

概述

• 产品名称
  Anti-CBFb抗体
  参阅全部 CBFb 一抗
• 描述
  兔多克隆抗体to CBFb
• 经测试应用
  适用于: WB, IPmore details
• 种属反应性
  与反应: Human
  预测可用于: Mouse, Rabbit, Horse, Dog, Chimpanzee, Rhesus monkey
• 免疫原

  Synthetic peptide, corresponding to a region within amino acids 166-187 of Human CBFb (NP_074036.1).

• 阳性对照
  • Jurkat whole cell lysate HeLa whole cell lysate 293T whole cell lysate

性能

• 形式
  Liquid
• 存放说明
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• 存储溶液
  Preservative: 0.09% Sodium azide
  Constituent: 99% Tris citrate/phosphate
  Note: pH 7 to 8
• Concentration information loading...
• 纯度
  Immunogen affinity purified
• 克隆
  多克隆
• 同种型
  IgG
• 研究领域
  • Epigenetics and Nuclear Signaling
  • Transcription
  • Other factors

相关产品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Positive Controls
  • HeLa nuclear extract lysate (ab14655)
  • Jurkat nuclear extract lysate (ab14844)
  • HeLa whole cell lysate (ab29545)
  • Jurkat whole cell lysate (ab7899)
  • 293T whole cell lysate (ab95494)

应用

靶标

• 功能
  CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBFB enhances DNA binding by RUNX1.
• 疾病相关
  Note=A chromosomal aberration involving CBFB is associated with acute myeloid leukemia of M4EO subtype. Pericentric inversion inv(16)(p13;q22). The inversion produces a fusion protein that consists of the 165 N-terminal residues of CBF-beta (PEPB2) with the tail region of MYH11.
• 序列相似性
  Belongs to the CBF-beta family.
• 细胞定位
  Nucleus.

• Target information above from: UniProt accession Q13951 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 479690 Dog
  • Entrez Gene: 865 Human
  • Entrez Gene: 12400 Mouse
  • Omim: 121360 Human
  • SwissProt: Q13951 Human
  • SwissProt: Q08024 Mouse
  • Unigene: 460988 Human
  • Unigene: 2018 Mouse
• 别名
  • CBF b antibody
  • CBF beta antibody
  • CBF-beta antibody

  • CBFB antibody
  • CBFbeta antibody
  • Core binding factor beta subunit antibody
  • core binding factor subunit beta antibody
  • Core-binding factor subunit beta antibody
  • PEA 2 antibody
  • PEA2 antibody
  • PEA2 beta antibody
  • PEA2-beta antibody
  • PEA2beta antibody
  • PEBB_HUMAN antibody
  • PEBP 2B antibody
  • PEBP2 beta antibody
  • PEBP2-beta antibody
  • PEBP2B antibody
  • PEBP2beta antibody
  • Polyomavirus enhancer binding protein 2 beta subunit antibody
  • Polyomavirus enhancer-binding protein 2 beta subunit antibody
  • SL3 3 enhancer factor 1 beta subunit antibody
  • SL3 3 enhancer factor 1 subunit beta antibody
  • SL3-3 enhancer factor 1 subunit beta antibody
  • SL3/AKV core binding factor beta subunit antibody
  • SL3/AKV core-binding factor beta subunit antibody

  see all

实验方案

• Western blot protocols
• Immunoprecipitation protocols