概述

  • 产品名称Anti-CBFA2T3抗体
    参阅全部 CBFA2T3 一抗
  • 描述
    兔多克隆抗体to CBFA2T3
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthetic peptide derived from internal sequence of Human CBFA2T3.

  • 阳性对照
    • Human brain tissue

性能

应用

Our Abpromise guarantee covers the use of ab110823 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation.
    Isoform 2 functions as an A-kinase-anchoring protein.
  • 组织特异性Widely expressed with higher expression in heart, pancreas, skeletal muscle, spleen, thymus and peripheral blood leukocytes. Expressed in hematopoietic cells (at protein level).
  • 疾病相关Note=A chromosomal aberration involving CBFA2T3 is found in therapy-related myeloid malignancies. Translocation t(16;21)(q24;q22) that forms a RUNX1-CBFA2T3 fusion protein.
  • 序列相似性Belongs to the CBFA2T family.
    Contains 1 MYND-type zinc finger.
    Contains 1 TAFH (NHR1) domain.
  • 细胞定位Nucleus > nucleolus. The RUNX1-CBFA2T3 fusion protein localizes to the nucleoplasm and Nucleus > nucleoplasm. Golgi apparatus membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Cbfa2t3 antibody
    • Ccore binding factor runt domain alpha subunit 2 translocated to 3 antibody
    • ETO2 antibody
    • hMTG16 antibody
    • hMTG16a antibody
    • hMTG16b antibody
    • MTG16 antibody
    • MTG16_HUMAN antibody
    • MTG8 related gene 2 antibody
    • MTG8 related protein MTG16a antibody
    • MTG8 related protein MTG16b antibody
    • MTG8-related protein 2 antibody
    • MTGR2 antibody
    • Myeloid translocation gene 8 and 16b antibody
    • Myeloid translocation gene on chromosome 16 protein antibody
    • Protein CBFA2T3 antibody
    • Zinc finger MYND domain-containing protein 4 antibody
    • ZMYND4 antibody
    see all

Anti-CBFA2T3 antibody 图像

  • ab110823, at 1/50 dilution, staining CBFA2T3 in paraffin-embedded Human brain tissue by Immunohistochemistry, in the presence (right panel) or absence (left panel) of immunising peptide.

Anti-CBFA2T3 antibody (ab110823)参考文献

ab110823 has not yet been referenced specifically in any publications.

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