概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • AccessionQ9WVC3
    • 种属Mouse
    • 序列MGLETEKADVQLFMADDAYC
    • 氨基酸1 to 19

相关产品

技术指标

Our Abpromise guarantee covers the use of ab4929 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式Liquid
  • 补充说明

     

    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and endogenous caveolin-2, catalog ab2911. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

常规信息

  • 别名
    • CAV
    • CAV2
    • CAV2_HUMAN
    • Caveolae protein 20 kD
    • Caveolin 2
    • Caveolin 2 isoform a and b
    • Caveolin-2
    • MGC12294
    • OTTHUMP00000025032
    • OTTHUMP00000195982
    see all
  • 功能May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression.
  • 组织特异性Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts.
  • 序列相似性Belongs to the caveolin family.
  • 翻译后修饰Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on Ser-36 appears to modulate mitosis in endothelial cells (By similarity). Phosphorylation on both Tyr-19 and Tyr-27 is required for insulin-induced 'Ser-727' phosphorylation of STAT3 and its activation. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin.
  • 细胞定位Nucleus. Cytoplasm. Golgi apparatus membrane. Cell membrane. Membrane > caveola. Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By similarity). Tyr-27-phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments.
  • Information by UniProt

Caveolin-2 peptide (ab4929)参考文献

ab4929 has not yet been referenced specifically in any publications.

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