Anti-Caveolin-1抗体[AT4C1] (ab106642)

概述

  • 产品名称Anti-Caveolin-1抗体[AT4C1]
    参阅全部 Caveolin-1 一抗
  • 描述
    小鼠单克隆抗体[AT4C1] to Caveolin-1
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Rat, Human
  • 免疫原

    Recombinant fragment corresponding to Human Caveolin-1 aa 1-104. Recombinant fragment, corresponding to amino acids 1-104 of Human Caveolin-1 purified from E. coli (NP_001744)
    Database link: Q03135

  • 阳性对照
    • Rat brain lysates

性能

应用

Our Abpromise guarantee covers the use of ab106642 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/250 - 1/1000. Predicted molecular weight: 20 kDa.
ELISA Use at an assay dependent dilution.

靶标

  • 功能May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway.
  • 组织特异性Expressed in muscle and lung, less so in liver, brain and kidney.
  • 疾病相关Defects in CAV1 are the cause of congenital generalized lipodystrophy type 3 (CGL3) [MIM:612526]; also called Berardinelli-Seip congenital lipodystrophy type 3 (BSCL3). Congenital generalized lipodystrophies are autosomal recessive disorders characterized by a near absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes.
  • 序列相似性Belongs to the caveolin family.
  • 翻译后修饰The initiator methionine for isoform Beta is removed during or just after translation. The new N-terminal amino acid is then N-acetylated.
  • 细胞定位Golgi apparatus membrane. Cell membrane. Membrane > caveola. Membrane raft. Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae.
  • Information by UniProt
  • 数据库链接
  • 别名
    • BSCL3 antibody
    • CAV antibody
    • CAV1 antibody
    • CAV1_HUMAN antibody
    • caveolae protein, 22 kD antibody
    • caveolin 1 alpha isoform antibody
    • caveolin 1 beta isoform antibody
    • Caveolin 1 caveolae protein 22kDa antibody
    • Caveolin-1 antibody
    • Caveolin1 antibody
    • cell growth-inhibiting protein 32 antibody
    • CGL3 antibody
    • LCCNS antibody
    • MSTP085 antibody
    • OTTHUMP00000025031 antibody
    • PPH3 antibody
    • VIP 21 antibody
    • VIP21 antibody
    see all

Anti-Caveolin-1 antibody [AT4C1] 图像

  • Anti-Caveolin-1 antibody [AT4C1] (ab106642) at 1/1000 dilution + Rat brain lysate at 40 µg

    Secondary
    Goat anti-mouse HRP conjugated
    Developed using the ECL technique

    Predicted band size : 20 kDa

Anti-Caveolin-1 antibody [AT4C1] (ab106642)参考文献

ab106642 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab106642.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"