概述

  • 产品名称Anti-Caveolin-1抗体
    参阅全部 Caveolin-1 一抗
  • 描述
    兔多克隆抗体to Caveolin-1
  • 经测试应用适用于: WB, ICC/IF, ELISAmore details
  • 种属反应性
    与反应: Rabbit, Human
  • 免疫原

    Recombinant fragment corresponding to Human Caveolin-1 (N terminal).
    Database link: Q03135

  • 阳性对照
    • Rabbit spleen fibroblasts; A431 cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab86711 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/2000. Detects a band of approximately 21 kDa.
ICC/IF 1/100.
ELISA 1/4000.

靶标

  • 功能May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway.
  • 组织特异性Expressed in muscle and lung, less so in liver, brain and kidney.
  • 疾病相关Defects in CAV1 are the cause of congenital generalized lipodystrophy type 3 (CGL3) [MIM:612526]; also called Berardinelli-Seip congenital lipodystrophy type 3 (BSCL3). Congenital generalized lipodystrophies are autosomal recessive disorders characterized by a near absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes.
  • 序列相似性Belongs to the caveolin family.
  • 翻译后修饰The initiator methionine for isoform Beta is removed during or just after translation. The new N-terminal amino acid is then N-acetylated.
  • 细胞定位Golgi apparatus membrane. Cell membrane. Membrane > caveola. Membrane raft. Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae.
  • Information by UniProt
  • 数据库链接
  • 别名
    • BSCL3 antibody
    • CAV antibody
    • CAV1 antibody
    • CAV1_HUMAN antibody
    • caveolae protein, 22 kD antibody
    • caveolin 1 alpha isoform antibody
    • caveolin 1 beta isoform antibody
    • Caveolin 1 caveolae protein 22kDa antibody
    • Caveolin-1 antibody
    • Caveolin1 antibody
    • cell growth-inhibiting protein 32 antibody
    • CGL3 antibody
    • LCCNS antibody
    • MSTP085 antibody
    • OTTHUMP00000025031 antibody
    • PPH3 antibody
    • VIP 21 antibody
    • VIP21 antibody
    see all

Anti-Caveolin-1 antibody 图像

  • All lanes : Anti-Caveolin-1 antibody (ab86711) at 1/2000 dilution

    Lane 1 : A431 cells, unstimulated
    Lane 2 : A431 cells, stimulated with pervanadate (1 mM for 30 min)


    Observed band size : 21 kDa (why is the actual band size different from the predicted?)
  • IF staining of Caveolin-1 in PFA-fixed and NP40-permeabilized Rabbit spleen fibroblasts.
    The cells were labeled with ab86711 at 1/100 dilution and detected using a secondary antibody conjugated to Cy3.
    Phase contrast image (left) and immunofluorescent image (right).

Anti-Caveolin-1 antibody (ab86711)参考文献

ab86711 has not yet been referenced specifically in any publications.

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