Anti-Cathepsin K抗体- Catalytic domain (ab49893)

概述

  • 产品名称Anti-Cathepsin K抗体- Catalytic domain
    参阅全部 Cathepsin K 一抗
  • 描述
    兔多克隆抗体to Cathepsin K - Catalytic domain
  • 特异性ab49893 recognizes all three forms of Cathepsin K (but does not see the 258 amino acid form as well as the other two forms, due to a partial deletion of the sequence).
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide based on the catalytic domain of human Cathepsin K.

性能

应用

Our Abpromise guarantee covers the use of ab49893 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent dilution. Predicted molecular weight: 37 kDa. A recommended starting concentration for Western blots is 1/1000 when using colorimetric substrates such as BCIP/NBT and 1/5000 for chemiluminescent substrates.

靶标

  • 功能Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.
  • 组织特异性Predominantly expressed in osteclasts (bones).
  • 疾病相关Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:265800]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.
  • 序列相似性Belongs to the peptidase C1 family.
  • 细胞定位Lysosome.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Cathepsin K antibody
    • Cathepsin O antibody
    • Cathepsin O1 antibody
    • Cathepsin O2 antibody
    • Cathepsin X antibody
    • CATK_HUMAN antibody
    • CTS02 antibody
    • Ctsk antibody
    • CTSO antibody
    • CTSO1 antibody
    • CTSO2 antibody
    • MGC23107 antibody
    • PKND antibody
    • PYCD antibody
    see all

Anti-Cathepsin K antibody - Catalytic domain 图像

  • All lanes : Anti-Cathepsin K antibody - Catalytic domain (ab49893) at 1/1000 dilution

    Lane 1 : r-Human Cathepsin K at 0.04 µg
    Lane 2 : r-Human Cathepsin K at 0.02 µg
    Lane 3 : r-Human Cathepsin K at 0.01 µg
    Lane 4 : r-Human Cathepsin K at 0.004 µg
    Lane 5 : r-Human Cathepsin K at 0.002 µg


    Predicted band size : 37 kDa

Anti-Cathepsin K antibody - Catalytic domain (ab49893)参考文献

ab49893 has not yet been referenced specifically in any publications.

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