概述

  • 产品名称Anti-Cathepsin K抗体
    参阅全部 Cathepsin K 一抗
  • 描述
    兔多克隆抗体to Cathepsin K
  • 特异性ab49892 recognizes all three forms of Cathepsin K (but does not see the 288 amino acid form as well as the other two forms, due to a partial deletion of the sequence). We have a range of domain specific antibodies for this target. For a full list please see all Cathepsin K antibodies.
  • 经测试应用适用于: ICC/IF, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide of Human Cathepsin K.

性能

应用

Our Abpromise guarantee covers the use of ab49892 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use at an assay dependent dilution. PubMed: 20435685
WB 1/1000 - 1/5000. Predicted molecular weight: 37 kDa.

靶标

  • 功能Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.
  • 组织特异性Predominantly expressed in osteclasts (bones).
  • 疾病相关Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:265800]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.
  • 序列相似性Belongs to the peptidase C1 family.
  • 细胞定位Lysosome.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Cathepsin K antibody
    • Cathepsin O antibody
    • Cathepsin O1 antibody
    • Cathepsin O2 antibody
    • Cathepsin X antibody
    • CATK_HUMAN antibody
    • CTS02 antibody
    • Ctsk antibody
    • CTSO antibody
    • CTSO1 antibody
    • CTSO2 antibody
    • MGC23107 antibody
    • PKND antibody
    • PYCD antibody
    see all

Anti-Cathepsin K antibody 图像

  • All lanes : Anti-Cathepsin K antibody (ab49892) at 1/1000 dilution

    Lane 1 : HOS cell lysate
    Lane 2 : HOS cell lysate
    Lane 3 : HOS cell lysate


    Predicted band size : 37 kDa
    Observed band size : 26,46 kDa (why is the actual band size different from the predicted?)

Anti-Cathepsin K antibody (ab49892)参考文献

This product has been referenced in:
  • Singh SR  et al. Can lineage-specific markers be identified to characterize mesenchyme-derived cell populations in the human airways? Am J Physiol Lung Cell Mol Physiol 299:L169-83 (2010). ICC/IF ; Human . Read more (PubMed: 20435685) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"