Anti-Cathepsin D抗体, prediluted (ab925)


  • 产品名称
    Anti-Cathepsin D抗体, prediluted
    参阅全部 Cathepsin D 一抗
  • 描述
    兔多克隆抗体to Cathepsin D, prediluted
  • 经测试应用
    适用于: IHC-P, IHC-Frmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Cathepsin D isolated from human liver.



Our Abpromise guarantee covers the use of ab925 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
  • 应用说明
    This antibody has been pretitered and quality controlled to work on formalin-fixed paraffin-embedded as well as acetone fixed cryostat tissue sections.
    No further titration is required.
    We suggest an incubation period of 30-60 minutes at room temperature.
    However, depending upon the fixation conditions and the staining system employed, optimal incubation should be determined by the user.
  • 靶标

    • 功能
      Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
    • 组织特异性
      Expressed in the aorta extrcellular space (at protein level).
    • 疾病相关
      Ceroid lipofuscinosis, neuronal, 10
    • 序列相似性
      Belongs to the peptidase A1 family.
      Contains 1 peptidase A1 domain.
    • 翻译后修饰
      N- and O-glycosylated.
    • 细胞定位
      Lysosome. Melanosome. Secreted, extracellular space. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380).
    • Information by UniProt
    • 数据库链接
    • 别名
      • CatD antibody
      • CATD_HUMAN antibody
      • Cathepsin D antibody
      • Cathepsin D heavy chain antibody
      • CD antibody
      • Ceroid lipofuscinosis neuronal 10 antibody
      • CLN10 antibody
      • CPSD antibody
      • ctsd antibody
      • Epididymis secretory sperm binding protein Li 130P antibody
      • HEL S 130P antibody
      • Lysosomal aspartyl peptidase antibody
      • Lysosomal aspartyl protease antibody
      • MGC2311 antibody
      see all

    Anti-Cathepsin D antibody, prediluted (ab925)参考文献

    This product has been referenced in:
    • Zheng X  et al. Role of the proteolytic hierarchy between cathepsin L, cathepsin D and caspase-3 in regulation of cellular susceptibility to apoptosis and autophagy. Biochim Biophys Acta 1783:2294-300 (2008). Read more (PubMed: 18775751) »

    See 1 Publication for this product

    Product Wall

    Thank you for the details that you have provided and for your patience. Are you using a home made kit to stain this antibody with? This may not be as sensitive as a commercial kit, such as Dako's or Power Vision. At this point I would suggest increasin...

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    Thanks for your email. If you continue to experience difficulty with ab925 in IHC, please let me know. Just answer the questions below, and also include the lot number that you received (located on the vial), and the Abcam order number or purchase orde...

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    Thank you for your enquiry. The concentration is 0.10 mg/ml. Please note that this antibody has been pretitered and quality controlled to work on formalin-fixed paraffin-embedded as well as acetone fixed cryostat tissue sections and no further titratio...

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