Anti-Caspr2抗体[S67-25] (ab105581)

概述

  • 产品名称Anti-Caspr2抗体[S67-25]
    参阅全部 Caspr2 一抗
  • 描述
    小鼠单克隆抗体[S67-25] to Caspr2
  • 特异性No cross-reactivity to CASPR/Paranodin.
  • 经测试应用适用于: WB, IHC-P, IHC-Fr, ICC/IFmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Fusion protein(his-tagged), corresponding to the extracellular domain amino acids 96-1265 of Human Caspr2 (NP_054860).

  • 阳性对照
    • Rat brain lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: 50% Glycerol, PBS, pH 7.4
  • Concentration information loading...
  • 纯度Protein G purified
  • 克隆单克隆
  • 克隆编号S67-25
  • 同种型IgG2a
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab105581 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 148 kDa.
IHC-P Use a concentration of 0.1 - 1 µg/ml.
IHC-Fr Use a concentration of 0.1 - 1 µg/ml.
ICC/IF Use a concentration of 0.1 - 10 µg/ml.

靶标

  • 功能May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction.
  • 组织特异性Predominantly expressed in nervous system.
  • 疾病相关Defects in CNTNAP2 are the cause of cortical dysplasia-focal epilepsy syndrome (CDFES) [MIM:610042]. Affected individuals manifest cortical dysplasia, focal epilepsy, relative macrocephaly, and diminished deep-tendon reflexes. Intractable focal seizures begin in early childhood, after which language regression, hyperactivity, impulsive and aggressive behavior, and mental retardation develop.
    Genetic variations in CNTNAP2 influences susceptibility to autism type 15 (AUTS15) [MIM:612100]. Autism is a neurodevelopmental disorder characterized by disturbance in language, perception and socialization. The disorder is classically defined by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, stereotypical, and ritualized patterns of interests and behavior.
    Note=A chromosomal aberration involving CNTNAP2 is found in a patient with autism spectrum disorder. Paracentric inversion 46,XY,inv(7)(q11.22;q35). The inversion breakpoints disrupt the genes AUTS2 and CNTNAP2.
  • 序列相似性Belongs to the neurexin family.
    Contains 2 EGF-like domains.
    Contains 1 F5/8 type C domain.
    Contains 1 fibrinogen C-terminal domain.
    Contains 4 laminin G-like domains.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AUTS15 antibody
    • CDFE antibody
    • Cell recognition molecule Caspr2 antibody
    • CNTNAP2 antibody
    • CNTP2 antibody
    • CNTP2_HUMAN antibody
    • Contactin-associated protein-like 2 antibody
    • Homolog of Drosophila neurexin IV antibody
    • NRXN4 antibody
    • PTHSL1 antibody
    see all

Anti-Caspr2 antibody [S67-25] 图像

  • Immunohistochemical detection of CASPR2 in frozen sections of Mouse brain extract using ab105581.


  • Predicted band size : 148 kDa
    Western blot detection of CASPR2 on Rat brain membrane tissues using ab105581 at 1:1000 dilution.

Anti-Caspr2 antibody [S67-25] (ab105581)参考文献

ab105581 has not yet been referenced specifically in any publications.

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