概述

  • 产品名称Anti-Caspase-7抗体[10-1-62]
    参阅全部 Caspase-7 一抗
  • 描述
    小鼠单克隆抗体[10-1-62] to Caspase-7
  • 特异性Ab28130 recognises Caspase-7, recombinant caspase-7 as well as full length pro caspase-7 and processed enzyme.
  • 经测试应用适用于: IHC-P, WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Hamster, Human, Monkey
  • 免疫原

    Recombinant full length protein corresponding to Human Caspase-7.
    Database link: P55210

  • 阳性对照
    • HeLa and Jurkat cell lysates.

性能

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应用

Our Abpromise guarantee covers the use of ab28130 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use at an assay dependent concentration.
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 34 kDa.

靶标

  • 功能Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-
    -Gly-217' bond. Overexpression promotes programmed cell death.
  • 组织特异性Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain.
  • 序列相似性Belongs to the peptidase C14A family.
  • 翻译后修饰Cleavages by granzyme B or caspase-10 generate the two active subunits. Propeptide domains can also be cleaved efficiently by caspase-3. Active heterodimers between the small subunit of caspase-7 and the large subunit of caspase-3, and vice versa, also occur.
  • 细胞定位Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Apoptotic protease Mch-3 antibody
    • Apoptotic protease MCH3 antibody
    • CASP-7 antibody
    • CASP7 antibody
    • CASP7_HUMAN antibody
    • Caspase 7 antibody
    • Caspase 7 apoptosis related cysteine peptidase antibody
    • Caspase-7 subunit p11 antibody
    • Caspase7 antibody
    • CMH 1 antibody
    • CMH-1 antibody
    • CMH1 antibody
    • ICE LAP3 antibody
    • ICE-LAP3 antibody
    • ICE-like apoptotic protease 3 antibody
    • LICE2 antibody
    • MCH3 antibody
    see all

Anti-Caspase-7 antibody [10-1-62] 图像

  • Immunohistochemistry paraffin embedded sections analysis of Human colon tissue sections labeling Caspase-7 with ab28130 at 10µg/ml.

  • Immunohistochemistry paraffin embedded sections analysis of Human spleen tissue sections labeling Caspase-7 with ab28130 at 10µg/ml.



  • Predicted band size : 34 kDa

    Western Blot analysis of human Jurkat and Jurkat induced cell lysates, probed with Caspase-7 antibody (ab28130).

Anti-Caspase-7 antibody [10-1-62] (ab28130)参考文献

This product has been referenced in:
  • Feng H  et al. Evidence for a Novel, Caspase-8-Independent, Fas Death Domain-Mediated Apoptotic Pathway. J Biomed Biotechnol 2004:41-51 (2004). Read more (PubMed: 15123887) »

See 1 Publication for this product

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