概述

  • 产品名称
    Anti-Caspase 4抗体
    参阅全部 Caspase 4 一抗
  • 描述
    兔多克隆抗体to Caspase 4
  • 宿主
    Rabbit
  • 特异性
    ab25898 recognises Caspase-4.
  • 经测试应用
    适用于: ICC/IF, WB, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic 16 amino acid peptide from the amino terminus of Caspase-4(Human)

  • 阳性对照
    • Mouse spleen. Ramos cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab25898 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 µg/ml. Detects a band of approximately 34 kDa (predicted molecular weight: 31 kDa).
IHC-P Use a concentration of 2 µg/ml.

靶标

  • 功能
    Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1.
  • 组织特异性
    Widely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain.
  • 序列相似性
    Belongs to the peptidase C14A family.
    Contains 1 CARD domain.
  • 翻译后修饰
    The two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Apoptotic cysteine protease Mih1/TX antibody
    • CASP-4 antibody
    • CASP4 antibody
    • CASP4_HUMAN antibody
    • Caspase 4 apoptosis related cysteine peptidase antibody
    • Caspase-4 subunit 2 antibody
    • Caspase4 antibody
    • ICE(rel)-II antibody
    • ICE(rel)II antibody
    • ICEREL II antibody
    • ICH2 antibody
    • Mih1/TX antibody
    • Protease ICH-2 antibody
    • Protease TX antibody
    • TX antibody
    see all

图片

  • Lane 1 : Anti-Caspase 4 antibody (ab25898) at 0.5 µg/ml
    Lane 2 : Anti-Caspase 4 antibody (ab25898) at 1 µg/ml

    All lanes : Ramos cell lysate

    Predicted band size: 31 kDa
    Observed band size: ~34 kDa (why is the actual band size different from the predicted?)

  • ab25898 Immunohistochemical staining Caspase 4 of mouse spleen using 2 µg/ml (paraffin embedded sections).

文献

This product has been referenced in:
  • Ghavami S  et al. Apoptosis, autophagy and ER stress in mevalonate cascade inhibition-induced cell death of human atrial fibroblasts. Cell Death Dis 3:e330 (2012). WB ; Human . Read more (PubMed: 22717585) »
  • Sansanwal P  et al. Caspase-4 may play a role in loss of proximal tubules and renal injury in nephropathic cystinosis. Pediatr Nephrol : (2009). IHC-P ; Human . Read more (PubMed: 19705160) »

See all 2 Publications for this product

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