概述

  • 产品名称Anti-Caspase 4抗体
    参阅全部 Caspase 4 一抗
  • 描述
    兔多克隆抗体to Caspase 4
  • 特异性ab22687 recognises proenzyme (43 kDa) and the large subunit (19 kDa) and small (10 kDa) subunits of mature enzyme. For the mature enzyme, reactivity is strongest with the large subunit. No cross reactivity with other human caspases tested (1 to 3, 5 to 10, 14).
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length protein (Human): Caspase 4

性能

应用

Our Abpromise guarantee covers the use of ab22687 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: 1/8000 - 1/16000. Detects bands of approximately 43, 19 and 10 kDa corresponding to the proenzyme, the large subunit and small subunits of mature enzyme, respectively (using Alkaline phosphatase-linked secondary antibody).

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1.
    • 组织特异性Widely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain.
    • 序列相似性Belongs to the peptidase C14A family.
      Contains 1 CARD domain.
    • 翻译后修饰The two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Apoptotic cysteine protease Mih1/TX antibody
      • CASP-4 antibody
      • CASP4 antibody
      • CASP4_HUMAN antibody
      • Caspase 4 apoptosis related cysteine peptidase antibody
      • Caspase-4 subunit 2 antibody
      • Caspase4 antibody
      • ICE(rel)-II antibody
      • ICE(rel)II antibody
      • ICEREL II antibody
      • ICH2 antibody
      • Mih1/TX antibody
      • Protease ICH-2 antibody
      • Protease TX antibody
      • TX antibody
      see all

    Anti-Caspase 4 antibody (ab22687)参考文献

    This product has been referenced in:
    • Moorwood C & Barton ER Caspase-12 ablation preserves muscle function in the mdx mouse. Hum Mol Genet 23:5325-41 (2014). Read more (PubMed: 24879640) »
    • Park GB  et al. Endoplasmic Reticulum Stress-Mediated Apoptosis of EBV-Transformed B Cells by Cross-Linking of CD70 Is Dependent upon Generation of Reactive Oxygen Species and Activation of p38 MAPK and JNK Pathway. J Immunol 185:7274-84 (2010). WB . Read more (PubMed: 21078900) »

    See all 2 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"