Anti-Caspase-11抗体(ab22684)
Key features and details
- Rabbit polyclonal to Caspase-11
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术,可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-Caspase-11抗体
参阅全部 Caspase-11 一抗 -
描述
兔多克隆抗体to Caspase-11 -
宿主
Rabbit -
特异性
ab22684 recognises caspase-11 proenzyme (43 kD) and the large (23 kD) and small (10 kD) subunits of the mature enzyme. No crossreactivity with other caspases tested: mouse caspases-1 and 3, human caspases 1 to 10 and 14. -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse
不与反应: Human -
免疫原
Recombinant full length protein corresponding to Mouse Caspase-11.
Database link: P70343 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. -
存储溶液
Preservative: 0.05% Sodium azide -
Concentration information loading...
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纯度
Whole antiserum -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab22684于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
WB | (2) |
Use at an assay dependent concentration.
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说明 |
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WB
Use at an assay dependent concentration. |
靶标
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功能
Involved in ER-stress induced apoptosis. Cleaves caspase-1 (By similarity). Involved in the activation cascade of caspases responsible for apoptosis execution. Promotes IL-1 beta processing by ICE, so may also have a role in inflammatory responses. -
组织特异性
Mostly expressed in lung and spleen; weaker in heart and lung; little in liver, skeletal muscle, kidney and testis. Not found in the brain. -
序列相似性
Belongs to the peptidase C14A family.
Contains 1 CARD domain. -
翻译后修饰
The two subunits are derived from the precursor sequence by a autocatalytic mechanism. -
细胞定位
Endoplasmic reticulum membrane. Mitochondrion. - Information by UniProt
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数据库链接
- Entrez Gene: 12363 Mouse
- SwissProt: P70343 Mouse
- Unigene: 1569 Mouse
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别名
- CASP-11 antibody
- CASP-4 antibody
- CASP11 antibody
see all
数据表及文件
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Datasheet download
文献 (6)
ab22684 被引用在 6 文献中.
- Ye X et al. CircRNA circ-NNT mediates myocardial ischemia/reperfusion injury through activating pyroptosis by sponging miR-33a-5p and regulating USP46 expression. Cell Death Discov 7:370 (2021). PubMed: 34845193
- Wang J et al. CircHIPK3 Promotes Pyroptosis in Acinar Cells Through Regulation of the miR-193a-5p/GSDMD Axis. Front Med (Lausanne) 7:88 (2020). PubMed: 32318575
- Holani R et al. Cathelicidin-mediated lipopolysaccharide signaling via intracellular TLR4 in colonic epithelial cells evokes CXCL8 production. Gut Microbes 12:1785802 (2020). PubMed: 32658599
- Bi F et al. Rhein Protects Against Neurological Deficits After Traumatic Brain Injury in Mice via Inhibiting Neuronal Pyroptosis. Front Pharmacol 11:564367 (2020). PubMed: 33101024
- Xu J et al. Macrophage endocytosis of high-mobility group box 1 triggers pyroptosis. Cell Death Differ N/A:N/A (2014). PubMed: 24769733
- Kang MJ et al. IL-18 is induced and IL-18 receptor alpha plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation. J Immunol 178:1948-59 (2007). WB ; Mouse . PubMed: 17237446