概述

  • 产品名称Anti-Caspase-10抗体
    参阅全部 Caspase-10 一抗
  • 描述
    兔多克隆抗体to Caspase-10
  • 特异性ab25045 recognises the proform, intermediates and cleaved form of caspase-10.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to Human Caspase-10.
    Database link: Q92851
    (Peptide available as ab41705)

  • 阳性对照
    • Jurkat cells induced by camptothecin (2uM/ml).

性能

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应用

Our Abpromise guarantee covers the use of ab25045 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 2 - 4 µg/ml. Predicted molecular weight: 20, 30, 34 , 55 kDa.Can be blocked with Caspase-10 peptide (ab41705).

靶标

  • 功能Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-
    -AMC and Asp-Glu-Val-Asp-
    -AMC.
    Isoform C is proteolytically inactive.
  • 组织特异性Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.
  • 疾病相关Defects in CASP10 are the cause of autoimmune lymphoproliferative syndrome type 2A (ALPS2A) [MIM:603909]. ALPS2 is characterized by abnormal lymphocyte and dendritic cell homeostasis and immune regulatory defects.
    Defects in CASP10 are a cause of familial non-Hodgkin lymphoma (NHL) [MIM:605027]. NHL is a cancer that starts in cells of the lymph system, which is part of the body's immune system. NHLs can occur at any age and are often marked by enlarged lymph nodes, fever and weight loss.
    Defects in CASP10 are a cause of gastric cancer (GASC) [MIM:613659]. A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease.
  • 序列相似性Belongs to the peptidase C14A family.
    Contains 2 DED (death effector) domains.
  • 翻译后修饰Cleavage by granzyme B and autocatalytic activity generate the two active subunits.
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ALPS2 antibody
    • Apoptotic protease Mch-4 antibody
    • CASP 10 antibody
    • CASP-10 antibody
    • CASP10 antibody
    • CASPA_HUMAN antibody
    • Caspase 10 apoptosis related cysteine peptidase antibody
    • Caspase-10 subunit p12 antibody
    • FADD like ICE2 antibody
    • Fas associated death domain protein antibody
    • FAS-associated death domain protein interleukin-1B-converting enzyme 2 antibody
    • FLICE 2 antibody
    • FLICE2 antibody
    • ICE like apoptotic protease 4 antibody
    • ICE-like apoptotic protease 4 antibody
    • Interleukin 1B converting enzyme 2 antibody
    • MCH 4 antibody
    see all

Anti-Caspase-10 antibody 图像

  • Anti-Caspase-10 antibody (ab25045) + 2 microM/ml camptothecin treated Jurkat cells.

    Predicted band size : 20, 30, 34 , 55 kDa
    Observed band size : 20,30,34,55 kDa

Anti-Caspase-10 antibody (ab25045)参考文献

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See 1 Publication for this product

Product Wall

Thank you for your enquiry. ab25045 detects both a and b forms of caspase-10 (pro, intermediate and cleaved forms). The positive control immunoblot used on the datasheet of ab10452 was indeed tested on UNTREATED Jurkat cells. By western blottin...

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