Anti-Caspase-10抗体(ab25045)

概述

• 产品名称
  Anti-Caspase-10抗体
  参阅全部 Caspase-10 一抗
• 描述
  兔多克隆抗体to Caspase-10
• 特异性
  ab25045 recognises the proform, intermediates and cleaved form of caspase-10.
• 经测试应用
  适用于: WBmore details
• 种属反应性
  与反应: Mouse, Rat, Human
  
• 免疫原

  Synthetic peptide corresponding to Human Caspase-10.
  Database link: Q92851
  (Peptide available as ab41705)

• 阳性对照
  • Jurkat cells induced by camptothecin (2uM/ml).

性能

• 形式
  Liquid
• 存放说明
  Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle.
• 存储溶液
  Preservative: 0.02% Thimerosal (merthiolate)
  Constituents: 50% Glycerol, 1% BSA, PBS, pH 7.2
• Concentration information loading...
• 纯度
  Protein A purified
• 克隆
  多克隆
• 同种型
  IgG
• 研究领域
  • Cell Biology
  • Apoptosis
  • Intracellular
  • Caspases etc
  • Caspases

  • Cancer
  • Invasion/microenvironment
  • Apoptosis
  • Caspases

  • Cell Biology
  • Proteolysis / Ubiquitin
  • Proteolytic enzymes
  • Other proteases

  • Metabolism
  • Pathways and Processes
  • Metabolism processes
  • Apoptosis

  • Cancer
  • Cell Death
  • Apoptosis
  • Apoptotic Markers
  • Caspases

  • Cancer
  • Cell Death
  • Apoptosis
  • Metabolism

相关产品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Immunizing Peptide (Blocking)
  • Caspase-10 peptide (ab41705)

应用

靶标

• 功能
  Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-
  -AMC and Asp-Glu-Val-Asp-
  -AMC.
  Isoform C is proteolytically inactive.
• 组织特异性
  Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.
• 疾病相关
  Defects in CASP10 are the cause of autoimmune lymphoproliferative syndrome type 2A (ALPS2A) [MIM:603909]. ALPS2 is characterized by abnormal lymphocyte and dendritic cell homeostasis and immune regulatory defects.
  Defects in CASP10 are a cause of familial non-Hodgkin lymphoma (NHL) [MIM:605027]. NHL is a cancer that starts in cells of the lymph system, which is part of the body's immune system. NHLs can occur at any age and are often marked by enlarged lymph nodes, fever and weight loss.
  Defects in CASP10 are a cause of gastric cancer (GASC) [MIM:613659]. A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease.
• 序列相似性
  Belongs to the peptidase C14A family.
  Contains 2 DED (death effector) domains.
• 翻译后修饰
  Cleavage by granzyme B and autocatalytic activity generate the two active subunits.
  Phosphorylated upon DNA damage, probably by ATM or ATR.

• Target information above from: UniProt accession Q92851 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 843 Human
  • Omim: 601762 Human
  • SwissProt: Q92851 Human
  • Unigene: 5353 Human
• 别名
  • ALPS2 antibody
  • Apoptotic protease Mch-4 antibody
  • CASP 10 antibody

  • CASP-10 antibody
  • CASP10 antibody
  • CASPA_HUMAN antibody
  • Caspase 10 apoptosis related cysteine peptidase antibody
  • Caspase-10 subunit p12 antibody
  • FADD like ICE2 antibody
  • Fas associated death domain protein antibody
  • FAS-associated death domain protein interleukin-1B-converting enzyme 2 antibody
  • FLICE 2 antibody
  • FLICE2 antibody
  • ICE like apoptotic protease 4 antibody
  • ICE-like apoptotic protease 4 antibody
  • Interleukin 1B converting enzyme 2 antibody
  • MCH 4 antibody

  see all

实验方案

• Western blot protocols