概述
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产品名称Anti-Caspase-1抗体
参阅全部 Caspase-1 一抗 -
描述兔多克隆抗体to Caspase-1
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经测试应用适用于: WB, IP, IHC-Pmore details
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种属反应性与反应: Human
预测可用于: Mouse, Rat
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免疫原
Synthetic peptide corresponding to Human Caspase-1.
Database link: P29466 -
阳性对照
- Jurkat cells. Human placenta.
性能
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形式Liquid
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存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle.
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存储溶液Preservative: 0.1% Sodium Azide
Constituents: 1% BSA, 10mM PBS, pH 7.4 -
Concentration information loading... -
纯度Protein A purified
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克隆多克隆
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同种型IgG
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研究领域
相关产品
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Compatible Secondaries
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Positive Controls
应用
Our Abpromise guarantee covers the use of ab74279 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | 1/100 - 1/200. Predicted molecular weight: 45 kDa. | |
| IP | 1/100 - 1/200. | |
| IHC-P | 1/50. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min. |
靶标
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功能Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.
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组织特异性Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.
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序列相似性Belongs to the peptidase C14A family.
Contains 1 CARD domain. -
翻译后修饰The two subunits are derived from the precursor sequence by an autocatalytic mechanism.
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细胞定位Cytoplasm.
- Information by UniProt
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数据库链接
- Entrez Gene: 834 Human
- Entrez Gene: 12362 Mouse
- Entrez Gene: 25166 Rat
- Omim: 147678 Human
- SwissProt: P29466 Human
- SwissProt: P29452 Mouse
- SwissProt: P43527 Rat
- Unigene: 2490 Human
see all -
别名
- CASP-1 antibody
- CASP1 antibody
- CASP1_HUMAN antibody
see all
Anti-Caspase-1 antibody 图像
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Caspase-1 antibody (ab74279)ab74279, at 1:50 dilution, staining Caspase-1 in formalin-fixed, paraffin-embedded human placenta tissue by immunohistochemistry.
Anti-Caspase-1 antibody (ab74279)参考文献
ab74279 has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"