概述

  • 产品名称
    Anti-Caspase-1抗体
    参阅全部 Caspase-1 一抗
  • 描述
    兔多克隆抗体to Caspase-1
  • 特异性
    ab62698 recognizes Caspase-1 subunit p10.
  • 经测试应用
    适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthetic peptide corresponding to Human Caspase-1.
    Database link: P29466

  • 阳性对照
    • Human brain tissue.

性能

应用

Our Abpromise guarantee covers the use of ab62698 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000.
ELISA 1/20000.
IHC-P 1/50 - 1/100.

靶标

  • 功能
    Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.
  • 组织特异性
    Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.
  • 序列相似性
    Belongs to the peptidase C14A family.
    Contains 1 CARD domain.
  • 翻译后修饰
    The two subunits are derived from the precursor sequence by an autocatalytic mechanism.
  • 细胞定位
    Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CASP-1 antibody
    • CASP1 antibody
    • CASP1_HUMAN antibody
    • Caspase 1 antibody
    • Caspase-1 subunit p10 antibody
    • ICE antibody
    • IL-1 beta-converting enzyme antibody
    • IL-1BC antibody
    • IL1 beta converting enzyme antibody
    • IL1B convertase antibody
    • Interleukin 1 beta convertase antibody
    • Interleukin 1B converting enzyme antibody
    • Interleukin-1 beta convertase antibody
    • Interleukin-1 beta-converting enzyme antibody
    • p45 antibody
    see all

Anti-Caspase-1 antibody 图像

  • ab62698 at a 1:50 dilution, staining Caspase-1 in paraffin embedded human brain tissue by Immunohistochemsitry in the absence (left image) or presence (right image) of the immunising peptide.

  • All lanes : Anti-Caspase-1 antibody (ab62698)

    Lane 1 : 293 cell extract
    Lane 2 : MCF-7 cell extract
    Lane 3 : HeLa cell extract
    Lane 4 : 293 cell extract with blocking peptide


    Observed band size : 29 kDa (why is the actual band size different from the predicted?)

Anti-Caspase-1 antibody (ab62698)参考文献

This product has been referenced in:
  • Hadadi E  et al. Differential IL-1ß secretion by monocyte subsets is regulated by Hsp27 through modulating mRNA stability. Sci Rep 6:39035 (2016). Flow Cyt . Read more (PubMed: 27976724) »

See 1 Publication for this product

Product Wall

Thank you for your inquiry. I can confirm that there is no BSA in the buffer and that the antibody recognizes Caspase-1 subunit p10.  There are no references citing the usage of this antibody in ELISA or IP.  As far as we're aware, this antibody ha...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

注册