概述

  • 产品名称Anti-Caspase-1抗体
    参阅全部 Caspase-1 一抗
  • 描述
    兔多克隆抗体to Caspase-1
  • 经测试应用适用于: ICC/IF, WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to Human Caspase-1.
    Database link: P29466

  • 阳性对照
    • HeLa cell lysate

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab62399 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 45 kDa (predicted molecular weight: 45 kDa).
IHC-P Use at an assay dependent concentration.

靶标

  • 功能Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.
  • 组织特异性Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.
  • 序列相似性Belongs to the peptidase C14A family.
    Contains 1 CARD domain.
  • 翻译后修饰The two subunits are derived from the precursor sequence by an autocatalytic mechanism.
  • 细胞定位Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CASP-1 antibody
    • CASP1 antibody
    • CASP1_HUMAN antibody
    • Caspase 1 antibody
    • Caspase-1 subunit p10 antibody
    • ICE antibody
    • IL-1 beta-converting enzyme antibody
    • IL-1BC antibody
    • IL1 beta converting enzyme antibody
    • IL1B convertase antibody
    • Interleukin 1 beta convertase antibody
    • Interleukin 1B converting enzyme antibody
    • Interleukin-1 beta convertase antibody
    • Interleukin-1 beta-converting enzyme antibody
    • p45 antibody
    see all

Anti-Caspase-1 antibody 图像

  • Lane 1 : Anti-Caspase-1 antibody (ab62399) at 0.5 µg/ml
    Lane 2 : Anti-Caspase-1 antibody (ab62399) at 1 µg/ml
    Lane 3 : Anti-Caspase-1 antibody (ab62399) at 2 µg/ml

    Lane 1 : HeLa cell lysate
    Lane 2 : HeLa cell lysate
    Lane 3 : HeLa cell lysate


    Predicted band size : 45 kDa
  • ab62399 at 10 µg/ml staining human spleen tissue by IHC-P.
  • Immunofluorescence of Caspase-1 in Hela cells using ab62399 at 20 ug/ml.

Anti-Caspase-1 antibody (ab62399)参考文献

ab62399 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab62399.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"