概述

  • 产品名称Anti-CASK抗体
  • 描述
    兔多克隆抗体to CASK
  • 特异性By Western blot, this antibody detects a 112 kDa protein representing CASK from AtT20 cell lysate. Immunohistochemical staining of CASK in mouse brain with this antibody results in staining of the choroid plexus.
  • 经测试应用适用于: IHC-P, WBmore details
  • 种属反应性
    与反应: Mouse, Rat
    预测可用于: Human
  • 免疫原

    Synthetic peptide corresponding to Human CASK aa 578-592.
    Sequence:

    CERDSPSTSRQSPAN


    (Peptide available as ab4961)

  • 阳性对照
    • WB: AtT20 cell lysate IHC: mouse brain

性能

应用

Our Abpromise guarantee covers the use of ab3383 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use at an assay dependent concentration.
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 105 kDa.Can be blocked with CASK peptide (ab4961).

靶标

  • 功能Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TRB1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.
  • 组织特异性Ubiquitous. Expression is significantly greater in brain relative to kidney, lung, and liver and in fetal brain and kidney relative to lung and liver.
  • 疾病相关Defects in CASK are the cause of mental retardation X-linked CASK-related (MRXCASK) [MIM:300749]. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Patients with mental retardation X-linked CASK-related can manifest a severe phenotype consisting of severe intellectual deficit, congenital or postnatal microcephaly, disproportionate brainstem and cerebellar hypoplasia (MICPCH Syndrome). A milder phenotype consists of mental retardation alone or associated with nystagmus.
    Defects in CASK are the cause of FG syndrome type 4 (FGS4) [MIM:300422]. FG syndrome (FGS) is an X-linked disorder characterized by mental retardation, relative macrocephaly, hypotonia and constipation.
  • 序列相似性In the N-terminal section; belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
    Belongs to the MAGUK family.
    Contains 1 guanylate kinase-like domain.
    Contains 2 L27 domains.
    Contains 1 PDZ (DHR) domain.
    Contains 1 protein kinase domain.
    Contains 1 SH3 domain.
  • 结构域The first L27 domain binds DLG1 and the second L27 domain probably binds LIN7.
    The protein kinase domain mediates the interaction with FCHSD2.
  • 细胞定位Nucleus. Cytoplasm. Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CAGH39 antibody
    • Caki antibody
    • Calcium/calmodulin dependent serine protein kinase antibody
    • Calcium/calmodulin dependent serine protein kinase (MAGUK family) antibody
    • Calcium/calmodulin dependent serine protein kinase membrane associated guanylate kinase antibody
    • Calcium/calmodulin-dependent serine protein kinase antibody
    • CAMGUK antibody
    • CAMGUK protein antibody
    • CAMGUK, drosophila, homolog of antibody
    • casK antibody
    • CMG antibody
    • CSKP_HUMAN antibody
    • DXPri1 antibody
    • DXRib1 antibody
    • FGS4 antibody
    • FLJ22219 antibody
    • FLJ31914 antibody
    • hCASK antibody
    • LIN 2 antibody
    • Lin 2 homolog antibody
    • LIN2 antibody
    • Lin2 homolog antibody
    • MICPCH antibody
    • MRXSNA antibody
    • Pals3 antibody
    • Peripheral plasma membrane protein CASK antibody
    • Protein lin-2 homolog antibody
    • TNRC8 antibody
    • Trinucleotide repeat containing 8 antibody
    • Vertebtate LIN2 homolog antibody
    see all

Anti-CASK antibody 图像



  • Predicted band size : 105 kDa

    Western blot detection of CASK on AtT20 cell lysate using ab3383.

Anti-CASK antibody (ab3383)参考文献

This product has been referenced in:
  • Ojeh N  et al. The MAGUK-family protein CASK is targeted to nuclei of the basal epidermis and controls keratinocyte proliferation. J Cell Sci 121:2705-17 (2008). IHC ; Mouse, Rat . Read more (PubMed: 18664494) »

See 1 Publication for this product

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