Anti-Casein Kinase 1 delta抗体(ab48031)

概述

  • 产品名称Anti-Casein Kinase 1 delta抗体
    参阅全部 Casein Kinase 1 delta 一抗
  • 描述
    山羊多克隆抗体to Casein Kinase 1 delta
  • 特异性This antibody is expected to recognise both reported isoforms of Casein Kinase 1 delta
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow, Dog, Chimpanzee, Macaque Monkey
  • 免疫原

    Synthetic peptide:

    DREERLRHSRNPATR

    from the internal region of the protein (Human)

  • 阳性对照
    • HEK 293 cell lysate and lysates of Human Brain

性能

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应用

Our Abpromise guarantee covers the use of ab48031 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA
WB
  • 应用说明ELISA: Use at an assay dependent dilution.
    Antibody detection limit dilution 1/64,000.

    WB: Use at a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 48 kDa (predicted molecular weight: 47 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm.
    • 组织特异性Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. In blood, highly expressed in hemopoietic cells and mature granulocytes. Also found in monocytes and lymphocytes.
    • 疾病相关Defects in CSNK1D are a cause of familial advanced sleep-phase syndrome (FASPS) [MIM:604348]. FASPS is characterized by very early sleep onset and offset. Individuals are 'morning larks' with a 4 hours advance of the sleep, temperature and melatonin rhythms.
    • 序列相似性Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
      Contains 1 protein kinase domain.
    • 翻译后修饰Autophosphorylated on serine and threonine residues.
    • 细胞定位Cytoplasm. Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Casein kinase I delta isoform antibody
      • Casein kinase I isoform delta antibody
      • CKI delta antibody
      • CKI-delta antibody
      • CKId antibody
      • CKIdelta antibody
      • CSNK 1D antibody
      • CSNK1D antibody
      • HCKID antibody
      • KC1D_HUMAN antibody
      • Protein kinase CK1 delta antibody
      see all

    Anti-Casein Kinase 1 delta antibody 图像

    Anti-Casein Kinase 1 delta antibody (ab48031)参考文献

    This product has been referenced in:

    See 1 Publication for this product

    Product Wall

    Abcam guarantees this product to work in the species/application used in this Abreview.
    Application Western blot
    Sample Human Cell lysate - whole cell (HEK 293)
    Loading amount 20 µg
    Specification HEK 293
    Treatment DMSO, 24 hours
    Gel Running Conditions Non-reduced Denaturing (10)
    Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 21°C
    Username

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    Verified customer

    提交于 Nov 07 2011

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"