Anti-Casein Kinase 1 delta抗体(ab37971)

概述

  • 产品名称Anti-Casein Kinase 1 delta抗体
    参阅全部 Casein Kinase 1 delta 一抗
  • 描述
    兔多克隆抗体to Casein Kinase 1 delta
  • 特异性ab37971 recognizes Casein Kinase 1 delta.
  • 经测试应用适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    KLH conjugated synthetic peptide, derived from C terminal within residues 336-352 of Casein Kinase 1 delta (Human).

  • 阳性对照
    • HeLa cell lysate (WB), human breast carcinoma and human hepatocarcinoma tissue.

性能

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应用

Our Abpromise guarantee covers the use of ab37971 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Detects a band of approximately 47 kDa.
ELISA 1/1000.
IHC-P 1/50 - 1/100.

靶标

  • 功能Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm.
  • 组织特异性Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. In blood, highly expressed in hemopoietic cells and mature granulocytes. Also found in monocytes and lymphocytes.
  • 疾病相关Defects in CSNK1D are a cause of familial advanced sleep-phase syndrome (FASPS) [MIM:604348]. FASPS is characterized by very early sleep onset and offset. Individuals are 'morning larks' with a 4 hours advance of the sleep, temperature and melatonin rhythms.
  • 序列相似性Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
    Contains 1 protein kinase domain.
  • 翻译后修饰Autophosphorylated on serine and threonine residues.
  • 细胞定位Cytoplasm. Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Casein kinase I delta isoform antibody
    • Casein kinase I isoform delta antibody
    • CKI delta antibody
    • CKI-delta antibody
    • CKId antibody
    • CKIdelta antibody
    • CSNK 1D antibody
    • CSNK1D antibody
    • HCKID antibody
    • KC1D_HUMAN antibody
    • Protein kinase CK1 delta antibody
    see all

Anti-Casein Kinase 1 delta antibody 图像

  • Anti-Casein Kinase 1 delta antibody (ab37971) + HeLa cell lysate

    Secondary
    HRP-anti-rabbit

    Observed band size : 47 kDa (why is the actual band size different from the predicted?)
  • Formalin-fixed and paraffin-embedded human cancer tissue reacted with ab37971, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. HC = hepatocarcinoma.

Anti-Casein Kinase 1 delta antibody (ab37971)参考文献

ab37971 has not yet been referenced specifically in any publications.

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