Anti-Casein Kinase 1 delta抗体(ab123684)

概述

  • 产品名称
    Anti-Casein Kinase 1 delta抗体
    参阅全部 Casein Kinase 1 delta 一抗
  • 描述
    兔多克隆抗体to Casein Kinase 1 delta
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a sequence between internal sequence amino acids 203 - 231 of Mouse Casein Kinase 1 delta (NP_620690.1).

  • 阳性对照
    • Mouse heart tissue lysate

性能

应用

Our Abpromise guarantee covers the use of ab123684 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 47 kDa.

靶标

  • 功能
    Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm.
  • 组织特异性
    Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. In blood, highly expressed in hemopoietic cells and mature granulocytes. Also found in monocytes and lymphocytes.
  • 疾病相关
    Defects in CSNK1D are a cause of familial advanced sleep-phase syndrome (FASPS) [MIM:604348]. FASPS is characterized by very early sleep onset and offset. Individuals are 'morning larks' with a 4 hours advance of the sleep, temperature and melatonin rhythms.
  • 序列相似性
    Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
    Contains 1 protein kinase domain.
  • 翻译后修饰
    Autophosphorylated on serine and threonine residues.
  • 细胞定位
    Cytoplasm. Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Casein kinase I delta isoform antibody
    • Casein kinase I isoform delta antibody
    • CKI delta antibody
    • CKI-delta antibody
    • CKId antibody
    • CKIdelta antibody
    • CSNK 1D antibody
    • CSNK1D antibody
    • HCKID antibody
    • KC1D_HUMAN antibody
    • Protein kinase CK1 delta antibody
    see all

图片

  • Anti-Casein Kinase 1 delta antibody (ab123684) at 1/100 dilution + Mouse heart tissue lysate at 35 µg

    Predicted band size : 47 kDa

实验方案

文献

ab123684 has not yet been referenced specifically in any publications.

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