概述

  • 产品名称
    Anti-Casein Kinase 1 delta抗体
    参阅全部 Casein Kinase 1 delta 一抗
  • 描述
    山羊多克隆抗体to Casein Kinase 1 delta
  • 特异性
    ab10877 is specific for human casein kinase 1 delta.
  • 经测试应用
    适用于: ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide, corresponding to amino acids 310 - 327 of Human Casein Kinase 1 delta.

性能

应用

Our Abpromise guarantee covers the use of ab10877 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent dilution.
IHC-P 1/200. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

靶标

  • 功能
    Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm.
  • 组织特异性
    Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. In blood, highly expressed in hemopoietic cells and mature granulocytes. Also found in monocytes and lymphocytes.
  • 疾病相关
    Defects in CSNK1D are a cause of familial advanced sleep-phase syndrome (FASPS) [MIM:604348]. FASPS is characterized by very early sleep onset and offset. Individuals are 'morning larks' with a 4 hours advance of the sleep, temperature and melatonin rhythms.
  • 序列相似性
    Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
    Contains 1 protein kinase domain.
  • 翻译后修饰
    Autophosphorylated on serine and threonine residues.
  • 细胞定位
    Cytoplasm. Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Casein kinase I delta isoform antibody
    • Casein kinase I isoform delta antibody
    • CKI delta antibody
    • CKI-delta antibody
    • CKId antibody
    • CKIdelta antibody
    • CSNK 1D antibody
    • CSNK1D antibody
    • HCKID antibody
    • KC1D_HUMAN antibody
    • Protein kinase CK1 delta antibody
    see all

图片

  • ab10877 at 1/200 dilution staining Casein Kinase 1 delta in mouse skeletal muscle tissue section by Immunohistochemistry (PFA perfusion fixed frozen sections). Tissue samples from 4 to 6 week old BALB/c mice were immediately removed after killing and immersion fixed in Bouin's solution. Primary antibody was used for 40 minutes at RT. Specific antibody binding was visualised by the peroxidase reaction using DAB as substrate-chromogen.

文献

This product has been referenced in:
  • Lin SH  et al. Casein kinase 1 epsilon expression predicts poorer prognosis in low T-stage oral cancer patients. Int J Mol Sci 15:2876-91 (2014). IHC-P ; Human . Read more (PubMed: 24557581) »
  • Löhler J  et al. Immunohistochemical characterisation of cell-type specific expression of CK1delta in various tissues of young adult BALB/c mice. PLoS One 4:e4174 (2009). IHC-P ; Mouse . Read more (PubMed: 19137063) »

See all 4 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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