Anti-beta Casein抗体[F20.14] (ab47972)
Key features and details
- Mouse monoclonal [F20.14] to beta Casein
- Suitable for: IHC-P, IHC-Fr, WB
- Reacts with: Human
- Isotype: IgG1
概述
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产品名称
Anti-beta Casein抗体[F20.14]
参阅全部 beta Casein 一抗 -
描述
小鼠单克隆抗体[F20.14] to beta Casein -
宿主
Mouse -
特异性
This antibody reacts with beta-casein. The reactivity with alpha-casein has not been tested.
This antibody does not react with alpha lactalbumin. This antibody can be used as an in vitro marker of terminally differentiated breast lumenal epithelial cells.
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经测试应用
适用于: IHC-P, IHC-Fr, WBmore details -
种属反应性
与反应: Human -
免疫原
Full length protein corresponding to Human beta Casein.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
Preservative: 0.02% Sodium azide
Constituent: 99.98% PBS -
Concentration information loading...
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纯度
Protein A/G purified -
克隆
单克隆 -
克隆编号
F20.14 -
骨髓瘤
x63-Ag8.653 -
同种型
IgG1 -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab47972于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
IHC-P | (1) |
Use at an assay dependent concentration.
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IHC-Fr |
Use at an assay dependent concentration.
Fix with acetone. |
|
WB |
Use at an assay dependent concentration.
|
说明 |
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IHC-P
Use at an assay dependent concentration. |
IHC-Fr
Use at an assay dependent concentration. Fix with acetone. |
WB
Use at an assay dependent concentration. |
靶标
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功能
Important role in determination of the surface properties of the casein micelles. -
组织特异性
Mammary gland specific. Secreted in milk. -
序列相似性
Belongs to the beta-casein family. -
翻译后修饰
Form 1-P is phosphorylated once; half of the molecules are phosphorylated on Ser-24, half on Ser-25. -
细胞定位
Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 1447 Human
- Omim: 115460 Human
- SwissProt: P05814 Human
- Unigene: 2242 Human
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别名
- Beta-casein antibody
- CASB antibody
- CASB_HUMAN antibody
see all
数据表及文件
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SDS download
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Datasheet download
文献 (4)
ab47972 被引用在 4 文献中.
- Garner KEL et al. The Milk Protein Alpha-Casein Suppresses Triple Negative Breast Cancer Stem Cell Activity Via STAT and HIF-1alpha Signalling Pathways in Breast Cancer Cells and Fibroblasts. J Mammary Gland Biol Neoplasia 24:245-256 (2019). PubMed: 31529195
- Chew GL et al. Dynamic changes in high and low mammographic density human breast tissues maintained in murine tissue engineering chambers during various murine peripartum states and over time. Breast Cancer Res Treat 140:285-97 (2013). PubMed: 23881524
- Bonuccelli G et al. The milk protein a-casein functions as a tumor suppressor via activation of STAT1 signaling, effectively preventing breast cancer tumor growth and metastasis. Cell Cycle 11:3972-82 (2012). PubMed: 23047602
- Burchell J et al. Production and characterization of monoclonal antibodies to human casein. A monoclonal antibody that cross-reacts with casein and alpha-lactalbumin. Hybridoma 4:341-50 (1985). PubMed: 3905581