Anti-Cardiac Troponin I抗体(ab56357)

概述

  • 产品名称
    Anti-Cardiac Troponin I抗体
    参阅全部 Cardiac Troponin I 一抗
  • 描述
    山羊多克隆抗体to Cardiac Troponin I
  • 经测试应用
    适用于: IHC-Fr, WB, ELISAmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Full length native cardiac troponin I protein (purified) (Human)

性能

应用

Our Abpromise guarantee covers the use of ab56357 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-Fr Use at an assay dependent concentration.
WB Use at an assay dependent concentration.
ELISA Use at an assay dependent dilution.

靶标

  • 功能
    Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
  • 疾病相关
    Defects in TNNI3 are the cause of cardiomyopathy familial hypertrophic type 7 (CMH7) [MIM:613690]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
    Defects in TNNI3 are the cause of cardiomyopathy familial restrictive type 1 (RCM1) [MIM:115210]. RCM1 is an heart muscle disorder characterized by impaired filling of the ventricles with reduced diastolic volume, in the presence of normal or near normal wall thickness and systolic function.
    Defects in TNNI3 are the cause of cardiomyopathy dilated type 2A (CMD2A) [MIM:611880]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
    Defects in TNNI3 are the cause of cardiomyopathy dilated type 1FF (CMD1FF) [MIM:613286]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
  • 序列相似性
    Belongs to the troponin I family.
  • Information by UniProt
  • 数据库链接
  • 别名
    • cardiac muscle antibody
    • Cardiac troponin I antibody
    • cardiomyopathy, dilated 2A (autosomal recessive) antibody
    • Cardiomyopathy, familial hypertrophic, 7, included antibody
    • CMD1FF antibody
    • CMD2A antibody
    • CMH7 antibody
    • cTnI antibody
    • Familial hypertrophic cardiomyopathy 7 antibody
    • MGC116817 antibody
    • RCM1 antibody
    • Tn1 antibody
    • Tni antibody
    • TNN I3 antibody
    • TNNC 1 antibody
    • TNNC1 antibody
    • TNNI3 antibody
    • TNNI3_HUMAN antibody
    • Troponin I antibody
    • Troponin I cardiac antibody
    • Troponin I cardiac muscle antibody
    • Troponin I cardiac muscle isoform antibody
    • Troponin I type 3 cardiac antibody
    • troponin I, cardiac 3 antibody
    • TroponinI antibody
    • Ttroponin I type 3 (cardiac) antibody
    see all

文献

This product has been referenced in:
  • Fukuda R  et al. Proteolysis regulates cardiomyocyte maturation and tissue integration. Nat Commun 8:14495 (2017). IHC-P ; Mouse . Read more (PubMed: 28211472) »
  • Nakaya M  et al. Cardiac myofibroblast engulfment of dead cells facilitates recovery after myocardial infarction. J Clin Invest 127:383-401 (2017). IHC-Fr ; Mouse . Read more (PubMed: 27918308) »

See all 11 Publications for this product

客户评价及客户问答

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Our catalog number ab56357 does correspond to a Cardiac Troponin I antibody that is raised in goat. If you are looking for an alternative type of Troponin, please let me know and I will be happy to help you locate...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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