Anti-Cardiac Troponin C抗体[MAC 352] (ab51106)

概述

  • 产品名称Anti-Cardiac Troponin C抗体[MAC 352]
    参阅全部 Cardiac Troponin C 一抗
  • 描述
    大鼠单克隆抗体[MAC 352] to Cardiac Troponin C
  • 特异性Antibody reacts with Troponin C isoforms F1 and F2 in flight muscle of Lethocerus and Drosophila, and with Troponin C in non-flight muscles.
  • 经测试应用适用于: ICC/IF, Electron Microscopy, WBmore details
  • 种属反应性
    与反应: Drosophila melanogaster, Lethocerus indicus (Waterbug)
  • 免疫原

    Troponin C purified from Lethocerus indicus (Waterbug) flight muscle.

性能

应用

Our Abpromise guarantee covers the use of ab51106 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF
Electron Microscopy
WB
  • 应用说明Electron Microscopy: Use at an assay dependent dilution.
    ICC/IF: Use at an assay dependent dilution.
    WB: Use at an assay dependent dilution. Predicted molecular weight: 17 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
    • 疾病相关Defects in TNNC1 are the cause of cardiomyopathy dilated type 1Z (CMD1Z) [MIM:611879]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
      Defects in TNNC1 are the cause of familial hypertrophic cardiomyopathy type 13 (CMH13) [MIM:613243]. A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
    • 序列相似性Belongs to the troponin C family.
      Contains 4 EF-hand domains.
    • Information by UniProt
    • 别名
      • tnnc1a antibody
      • Cardiac troponin C antibody
      • slow skeletal and cardiac muscles antibody
      • TN-C antibody
      • TNC antibody
      • Tnnc1 antibody
      • TNNC1_HUMAN antibody
      • TNNI3 antibody
      • Troponin C antibody
      • Troponin C slow antibody
      • Troponin C1 slow antibody
      see all

    Anti-Cardiac Troponin C antibody [MAC 352] (ab51106)参考文献

    This product has been referenced in:
    • Chechenova MB  et al. The Drosophila Z-disc protein Z(210) is an adult muscle isoform of Zasp52, which is required for normal myofibril organization in indirect flight muscles. J Biol Chem 288:3718-26 (2013). WB, IHC-Fr ; Drosophila melanogaster . Read more (PubMed: 23271733) »
    • Agianian B  et al. A troponin switch that regulates muscle contraction by stretch instead of calcium. EMBO J 23:772-9 (2004). Read more (PubMed: 14765112) »

    See all 4 Publications for this product

    Product Wall

    There are currently no Abreviews or Questions for ab51106.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"